Mice With Human Livers Gastroenterology Markus Grompe, Stephen Strom  Gastroenterology  Volume 145, Issue 6, Pages 1209-1214 (December 2013) DOI: 10.1053/j.gastro.2013.09.009 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 Liver repopulation with human hepatocytes. (A) Human cells are injected intrasplenically and then subjected to in vivo selection. The percentage of human hepatocytes increases with time. (B) Repopulated FRG mouse livers. Fah staining is brown. The average replacement index is 70%–90%. Gastroenterology 2013 145, 1209-1214DOI: (10.1053/j.gastro.2013.09.009) Copyright © 2013 AGA Institute Terms and Conditions

Figure 2 Malaria infection in humanized mice. (A, B) Plasmodium falciparum liver stage infection in huFRG mice. Blue = DNA, red = antibody for parasite, green = Fah. Scale bar = 10 microns. (A) Day 3 after infection. A single early liver stage parasite is seen within a human hepatocyte. (B) Day 7. The parasite has replicated massively and ballooned the infected hepatocyte. (C) Mice were injected intravenously with transgenic Plasmodium falciparum sporozoites expressing a GFP-luciferase fusion protein. Liver stage development was imaged by luciferase expression at 6 days after sporozoite injection. The mouse on the right is a non-humanized control. The images were kindly provided by Ashley Vaughn and Sebastian Mikolajczak from the Seattle Biomedical Research Institute. Gastroenterology 2013 145, 1209-1214DOI: (10.1053/j.gastro.2013.09.009) Copyright © 2013 AGA Institute Terms and Conditions