Pancreatic Development and Disease David A. Cano, Matthias Hebrok, Martin Zenker  Gastroenterology  Volume 132, Issue 2, Pages 745-762 (February 2007) DOI: 10.1053/j.gastro.2006.12.054 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 Pancreatic organogenesis in mice. Yellow shading indicates the pancreatic region (epithelium and mesenchyme) within the developing endoderm. Formation of pancreatic bud begins at approximately E9. After extensive branching and growth, the pancreatic ductal epithelium differentiate into exocrine cells (green) and endocrine cells (blue and red), the latter of which migrate into the surrounding mesenchyme. In adult mice, 3 cell types are found: acinar, ductal, and endocrine cells. Gastroenterology 2007 132, 745-762DOI: (10.1053/j.gastro.2006.12.054) Copyright © 2007 AGA Institute Terms and Conditions

Figure 2 Temporal expression of Pdx1 in pancreatic progenitor cells determines pancreatic cell linage.70 Gastroenterology 2007 132, 745-762DOI: (10.1053/j.gastro.2006.12.054) Copyright © 2007 AGA Institute Terms and Conditions

Figure 3 Organogenesis of the pancreas: normal development, variations, and anomalies. The pancreas has its embryological origin as 2 buds, 1 developing on the ventral side of the duodenum immediately adjacent to the hepatic diverticulum and the other on the opposite side. As the stomach and duodenum rotate, the ventral bud and the pancreaticobiliary orifice move around. Ventral and dorsal buds fuse. The ventral bud forms the posterior part of the head and uncinate process, and the dorsal bud forms the remainder of the organ. (A) The main pancreatic duct (Wirsung) results from fusion of the ventral duct with the distal part of the dorsal duct. (B) The proximal part of the dorsal duct (Santorini) may be preserved with its own opening into the duodenum. (C) Lack of fusion of the ductal systems of ventral and dorsal pancreatic buds give rise to pancreas divisum. (D) An annular pancreas results from abnormal extension or rotation of part of the ventral bud on the anterior side of the duodenum. (E) Lack of the development of the dorsal bud leads to congenital short pancreas. Gastroenterology 2007 132, 745-762DOI: (10.1053/j.gastro.2006.12.054) Copyright © 2007 AGA Institute Terms and Conditions