Maryam Sayadi, Seiichiro Tanizaki, Michael Feig Biophysical Journal

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Presentation transcript:

Effect of Membrane Thickness on Conformational Sampling of Phospholamban from Computer Simulations Maryam Sayadi, Seiichiro Tanizaki, Michael Feig Biophysical Journal Volume 98, Issue 5, Pages 805-814 (March 2010) DOI: 10.1016/j.bpj.2009.11.015 Copyright © 2010 Biophysical Society Terms and Conditions

Figure 1 Energy landscape for PLB in different membrane models; (A) MM1, (B) MM2, (C) MM3, and (D) MM4. Representative structures for the clusters corresponding to the minima are shown in cartoon representation. NMR structures with PDB codes 1N7L and 2KB7 are mapped and shown as red x and green o, respectively (15,16). Biophysical Journal 2010 98, 805-814DOI: (10.1016/j.bpj.2009.11.015) Copyright © 2010 Biophysical Society Terms and Conditions

Figure 2 (A) Distribution of CP helix insertion. (B) Distribution of the TM helix (residues 25–52) insertion for different membrane models: MM1 (green solid line), MM2 (red dashed line), MM3 (blue dotted line), MM4 (black dash-dot line). Biophysical Journal 2010 98, 805-814DOI: (10.1016/j.bpj.2009.11.015) Copyright © 2010 Biophysical Society Terms and Conditions