Topics to cover • HIV • AIDS Origins Transmission and replication

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Virsuses: Human Immunodeficiency Syndrome & Acquired Immunodeficiency Syndrome

Topics to cover • HIV • AIDS Origins Transmission and replication Detection and treatments • AIDS

Dr. Beatrice Hahn & colleagues: Drs. Li and Keele

Red Capped Mangabey monkey Greater spot nose monkey SIV cpz almost identical to HIV 1 Humans

Pan troglodytes troglodytes Simian Virus (SIV cpz) almost identical to HIV 1

HIV

T lymphocyte in green and HIV in red

HIV: Structure and mechanism of replication

HIV-1 PARTICLE

Transmission of HIV

RETROVIRAL REPLICATION

HIV and helper T cells HOST CELLS: helper T lymphocyte, macrophages

Budding of HIV from T lymphocyte

Mechanism of Infection Infects Th cell VIRAL RNA Integrates into host DNA “activated” PROVIRAL DNA LYTIC STAGE storage LYSOGENIC STAGE

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