Cohort study of preoperative blood pressure and risk of 30-day mortality after elective non-cardiac surgery S. Venkatesan, P.R. Myles, H.J. Manning,

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Cohort study of preoperative blood pressure and risk of 30-day mortality after elective non-cardiac surgery S. Venkatesan, P.R. Myles, H.J. Manning, A.M. Mozid, C. Andersson, M.E. Jørgensen, J.G. Hardman, S.R. Moonesinghe, P. Foex, M. Mythen, M.P.W. Grocott, R.D. Sanders British Journal of Anaesthesia Volume 119, Issue 1, Pages 65-77 (July 2017) DOI: 10.1093/bja/aex056 Copyright © 2017 The Author(s) Terms and Conditions

Fig 1 STROBE diagram. British Journal of Anaesthesia 2017 119, 65-77DOI: (10.1093/bja/aex056) Copyright © 2017 The Author(s) Terms and Conditions

Fig 2 Unadjusted and fully adjusted spline graphs for the association between systolic BP, diastolic BP, and pulse pressure and perioperative mortality. Fully adjusted model adjusted for age, gender, atrial fibrillation, unstable angina, valvular heart disease, myocardial infarction, congestive heart failure, peripheral vascular disease, cerebrovascular disease, chronic obstructive pulmonary disease, liver disease, diabetes mellitus, renal disease, cancer, Charlson’s comorbidity score, smoking, alcohol, surgical risk scale, socioeconomic status (IMD 2010), number of BP measurements, statins, beta blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, alpha-2 agonists, loop diuretics, thiazide diuretics, aspirin, other antiplatelet drugs, and selective serotonin re-uptake inhibitors. British Journal of Anaesthesia 2017 119, 65-77DOI: (10.1093/bja/aex056) Copyright © 2017 The Author(s) Terms and Conditions

Fig 3 Unadjusted and fully adjusted spline graphs for the association between systolic BP, diastolic BP, and pulse pressure and postoperative mortality in patients in whom BP measurements were recorded between 8 and 84 days prior to surgery. Fully adjusted model adjusted for age, gender, atrial fibrillation, unstable angina, valvular heart disease, myocardial infarction, congestive heart failure, peripheral vascular disease, cerebrovascular disease, chronic obstructive pulmonary disease, liver disease, diabetes mellitus, renal disease, cancer, Charlson’s comorbidity score, smoking, alcohol, surgical risk scale, socioeconomic status (IMD 2010), number of BP measurements, statins, beta blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, alpha-2 agonists, loop diuretics, thiazide diuretics, aspirin, other antiplatelet drugs, and selective serotonin re-uptake inhibitors. British Journal of Anaesthesia 2017 119, 65-77DOI: (10.1093/bja/aex056) Copyright © 2017 The Author(s) Terms and Conditions

Fig 4 Unadjusted and fully adjusted spline graphs for the association between systolic BP, diastolic BP, and pulse pressure and postoperative mortality in patients ≥65 years of age. Fully adjusted model adjusted for age, gender, atrial fibrillation, unstable angina, valvular heart disease, myocardial infarction, congestive heart failure, peripheral vascular disease, cerebrovascular disease, chronic obstructive pulmonary disease, liver disease, diabetes mellitus, renal disease, cancer, Charlson’s comorbidity score, smoking, alcohol, surgical risk scale, socioeconomic status (IMD 2010), number of BP measurements, statins, beta blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, alpha-2 agonists, loop diuretics, thiazide diuretics, aspirin, other antiplatelet drugs, and selective serotonin re-uptake inhibitors. British Journal of Anaesthesia 2017 119, 65-77DOI: (10.1093/bja/aex056) Copyright © 2017 The Author(s) Terms and Conditions