Meta-analysis of estradiol for luteal phase support in in vitro fertilization/intracytoplasmic sperm injection  Na Huang, M.S., Bing Situ, M.S., Xiao Chen, Ph.D., Jianqiao Liu, M.D., Pengke Yan, M.D., Ph.D., Xinhuang Kang, Ph.D., Songzhi Kong, Ph.D., Min Huang, Ph.D.  Fertility and Sterility  Volume 103, Issue 2, Pages 367-373.e5 (February 2015) DOI: 10.1016/j.fertnstert.2014.10.029 Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Forest plot comparing the effect of E2 on CPR/PA (according to the route of administration of E2). The forest plot shows no benefit of E2 supplement during the luteal phase in IVF/ICSI cycles for different routes of administration: oral (top), vaginal (middle), and transdermal (bottom) in terms of CPR/PA. A random-effects model was used because the included studies had substantial heterogeneity regarding dosage or route of medication and treatment duration. Fertility and Sterility 2015 103, 367-373.e5DOI: (10.1016/j.fertnstert.2014.10.029) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Forest plot comparing the effect of E2 on CPR/PA (according to different doses given orally). The forest plot shows that no significant effect was observed for different daily doses of oral E2 in CPR/PA: 6 mg (top), 4 mg (middle), and 2 mg (bottom). A random-effects model was used. Fertility and Sterility 2015 103, 367-373.e5DOI: (10.1016/j.fertnstert.2014.10.029) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Funnel plot of the analysis for the effect of the different routes of administration of E2 on CPR/PA. The results of Eggers are shown to assess publication bias. Fertility and Sterility 2015 103, 367-373.e5DOI: (10.1016/j.fertnstert.2014.10.029) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Funnel plot of the analysis for the effect of different does of oral E2 on CPR/PA. The results of Eggers are shown to assess publication bias. Fertility and Sterility 2015 103, 367-373.e5DOI: (10.1016/j.fertnstert.2014.10.029) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 Forest plot of the comparison of CPR/PA (according to GnRH agonist or GnRH antagonist cycles). The forest plot shows the results of a meta-analysis of studies comparing the effect of E2 on CPR/PA with GnRH agonist (top) and GnRH antagonist (bottom); no significant effect was observed. A random-effects model was used. Fertility and Sterility 2015 103, 367-373.e5DOI: (10.1016/j.fertnstert.2014.10.029) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions