Mean±SEM values (n=14 per group) for 6 hourly sodium excretions during the 24 hours after diuretic dosing. Mean±SEM values (n=14 per group) for 6 hourly.

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Mean±SEM values (n=14 per group) for 6 hourly sodium excretions during the 24 hours after diuretic dosing. Mean±SEM values (n=14 per group) for 6 hourly sodium excretions during the 24 hours after diuretic dosing. In each panel, the first bar refers to the first administration when given alone on day 1, and the second to the first administration when given on day 8 after adaptation to the other diuretic. Response to bumetanide (A), dapagliflozin (B) and dapagliflozin + bumetanide (C) represent increases in Na+ excretion from the corresponding times of the previous days. *P<0.05, **P<0.01, ***P<0.005 (compared with day 1). Christopher S. Wilcox et al. J Am Heart Assoc 2018;7:e007046 © 2018 Christopher S. Wilcox et al.