Role of Right Ventricle and Dynamic Pulmonary Hypertension on Determining ΔVO2/ΔWork Rate FlatteningCLINICAL PERSPECTIVE by Francesco Bandera, Greta Generati,

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Role of Right Ventricle and Dynamic Pulmonary Hypertension on Determining ΔVO2/ΔWork Rate FlatteningCLINICAL PERSPECTIVE by Francesco Bandera, Greta Generati, Marta Pellegrino, Valeria Donghi, Eleonora Alfonzetti, Maddalena Gaeta, Simona Villani, and Marco Guazzi Circ Heart Fail Volume 7(5):782-790 September 16, 2014 Copyright © American Heart Association, Inc. All rights reserved.

Example of a typical Δoxygen consumption/Δwork rate (ΔVO2/ΔWR) flattening vs nonflattening patients; from top to bottom, ΔVO2/ΔWR (only exercise), O2 pulse/time (exercise and recovery), and heart rate (HR)/time (only exercise) graphs. Example of a typical Δoxygen consumption/Δwork rate (ΔVO2/ΔWR) flattening vs nonflattening patients; from top to bottom, ΔVO2/ΔWR (only exercise), O2 pulse/time (exercise and recovery), and heart rate (HR)/time (only exercise) graphs. Francesco Bandera et al. Circ Heart Fail. 2014;7:782-790 Copyright © American Heart Association, Inc. All rights reserved.

Percentage of patients with Δoxygen consumption/Δwork rate flattening (in red, group A) according to the distribution of different underlying diseases. Percentage of patients with Δoxygen consumption/Δwork rate flattening (in red, group A) according to the distribution of different underlying diseases. HCM indicates hypertrophic cardiomyopathy; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; HRpHR, high risk patients with hypertrophic remodeling; and MR/TR, mitral regurgitation or tricuspid regurgitation. Francesco Bandera et al. Circ Heart Fail. 2014;7:782-790 Copyright © American Heart Association, Inc. All rights reserved.

A, Systolic pulmonary artery pressure (SPAP) vs cardiac output (CO) at rest and exercise peak with slope values in groups A and B; B, Systolic arterial pressure (SAP) vs CO at rest and exercise peak with slope values in groups A and B; C, SPAP vs tricuspid annular plane systolic excursion (TAPSE; with their ratio expressed as mean±SD) at rest and exercise peak in groups A and B. A, Systolic pulmonary artery pressure (SPAP) vs cardiac output (CO) at rest and exercise peak with slope values in groups A and B; B, Systolic arterial pressure (SAP) vs CO at rest and exercise peak with slope values in groups A and B; C, SPAP vs tricuspid annular plane systolic excursion (TAPSE; with their ratio expressed as mean±SD) at rest and exercise peak in groups A and B. Francesco Bandera et al. Circ Heart Fail. 2014;7:782-790 Copyright © American Heart Association, Inc. All rights reserved.