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Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology.

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Presentation on theme: "Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology."— Presentation transcript:

1 Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Eur Heart J, Volume 40, Issue 27, 23 May 2019, Pages 2194–2202, The content of this slide may be subject to copyright: please see the slide notes for details.

2 Figure 1 Aetiology and mechanism of diagnosed isolated moderate or severe mitral regurgitation distribution in the ... Figure 1 Aetiology and mechanism of diagnosed isolated moderate or severe mitral regurgitation distribution in the community. The upper part of the graph represents the aetiology classification of mitral regurgitation. The left cartouche shows the distribution of functional mitral regurgitation between those with predominant left ventricular remodelling (FMR-v) and those with predominant atrial remodelling (FMR-a) with their respective potential causes. The central cartouche shows the distribution of causes of organic mitral regurgitation (OMR) dominated by degenerative mitral regurgitation. The left cartouche shows mixed mitral regurgitation, dominated by hypertrophic cardiomyopathy. The lower part of the graph shows the mechanisms of mitral regurgitation classified as Type I (normal valve movement), Type II (excessive movement), Type IIIa (restrictive movement in diastole), and Type IIIb (restrictive movement in systole). Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Eur Heart J, Volume 40, Issue 27, 23 May 2019, Pages 2194–2202, The content of this slide may be subject to copyright: please see the slide notes for details.

3 Figure 2 Distribution of aetiologies of isolated moderate or severe mitral regurgitation in the community by age ... Figure 2 Distribution of aetiologies of isolated moderate or severe mitral regurgitation in the community by age groups. Each column represents 100% an age group with its individual distribution of aetiologies (red: FMR-a, green: FMR-v, blue: OMR, yellow: Miscellaneous) of diagnosed isolated moderate or severe mitral regurgitation in the community. Note the marked predominance of organic mitral regurgitation in young patients, while functional MR with predominant atrial remodelling is limited to elderly patients and functional MR with predominant left ventricular remodelling is widely distributed. FMR-a, functional MR with predominant atrial remodelling; FMR-v, functional MR with predominant left ventricular remodelling; MR, mitral regurgitation; OMR, organic mitral regurgitation. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Eur Heart J, Volume 40, Issue 27, 23 May 2019, Pages 2194–2202, The content of this slide may be subject to copyright: please see the slide notes for details.

4 Figure 3 Survival after diagnosis by mitral regurgitation subsets
Figure 3 Survival after diagnosis by mitral regurgitation subsets. Each panel represents the Kaplan–Meier survival ... Figure 3 Survival after diagnosis by mitral regurgitation subsets. Each panel represents the Kaplan–Meier survival curve (red curve) and the expected survival (blue line) of functional MR with predominant atrial remodelling (A, left panel), functional MR with predominant left ventricular remodelling (B, central panel), and organic mitral regurgitation (C, right panel). Note the excess mortality in each subset with the a risk ratio to expected mortality indicated in each panel with its 95% confidence interval and P-value. FMR-a, functional MR with predominant atrial remodelling; FMR-v, functional MR with predominant left ventricular remodelling; OMR, organic mitral regurgitation. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Eur Heart J, Volume 40, Issue 27, 23 May 2019, Pages 2194–2202, The content of this slide may be subject to copyright: please see the slide notes for details.

5 Figure 4 Incidence of heart failure after diagnosis by mitral regurgitation subsets. Each curve represents the ... Figure 4 Incidence of heart failure after diagnosis by mitral regurgitation subsets. Each curve represents the incidence Kaplan–Meier curve of heart failure after diagnosis of isolated moderate or severe mitral regurgitation for the three major subsets of mitral regurgitation. Note the high incidence of heart failure in all subsets including organic mitral regurgitation but with high frequency in functional MR with predominant atrial remodelling and considerable incidence in functional MR with predominant left ventricular remodelling. FMR-a, functional MR with predominant atrial remodelling; FMR-v, functional MR with predominant left ventricular remodelling; OMR, organic mitral regurgitation. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Eur Heart J, Volume 40, Issue 27, 23 May 2019, Pages 2194–2202, The content of this slide may be subject to copyright: please see the slide notes for details.

6 Take home figure Top layer (below the title) indicated the distribution of mitral regurgitation causal categories. Below, the ... Take home figure Top layer (below the title) indicated the distribution of mitral regurgitation causal categories. Below, the second layer indicates the distribution and major characteristics of mitral regurgitation causes categorized as function mitral regurgitation (FMR) due to ventricular remodelling (FMR-v; left) or due to atrial enlargement (FMR-a center) and of organic mitral regurgitation (OMR right). Below each category are indicated the rate of mitral surgery during their lifetime and the rate of survival compared to their expected survival expressed as risk-ratio (RR) and 95% confidence interval within each cartouche. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) For permissions, please article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Eur Heart J, Volume 40, Issue 27, 23 May 2019, Pages 2194–2202, The content of this slide may be subject to copyright: please see the slide notes for details.

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