Oral HPV infection and persistence in patients with head and neck cancer  Patrizia Morbini, MD, PhD, Barbara Dal Bello, MD, PhD, Paola Alberizzi, MLS, Laura Mannarini, MD, PhD, Niccolò Mevio, MD, Matteo Garotta, MD, Federica Mura, MD, Carmine Tinelli, MD, Giulia Bertino, MD, Marco Benazzo, MD  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology  Volume 116, Issue 4, Pages 474-484 (October 2013) DOI: 10.1016/j.oooo.2013.06.019 Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 1 Photomicrographs showing p16INK4A diffuse immunoreactivity (A) and HR HPV ISH nuclear dot-like signal (B) in an HPV-associated nonkeratinizing oropharyngeal SCC, and the absence of p16 expression (C) and of ISH signal (D) in a keratinizing SCC of the tongue (A, C: diaminobenzidine tetrahydrochloride chromogen and hematoxylin nuclear counterstain; B, D: nitro-blue tetrazolium/5-bromo-4-chloro-3′-indolyphosphate chromogen and red counterstain II; magnification: A, C ×10; B, D ×20). Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2013 116, 474-484DOI: (10.1016/j.oooo.2013.06.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 2 Kaplan–Meier survival curves showing a significant association between clinical stage IV and DSS; the presence of HPV and HR HPV infections in tumor biopsies and in oral scrapings did not influence patient survival. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2013 116, 474-484DOI: (10.1016/j.oooo.2013.06.019) Copyright © 2013 Elsevier Inc. Terms and Conditions