Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease

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Presentation transcript:

Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease John D. Sheppard, MD, MMSc, Gail L. Torkildsen, MD, John D. Lonsdale, MD, Francis A. D'Ambrosio, MD, Eugene B. McLaurin, MD, Richard A. Eiferman, MD, Kathryn S. Kennedy, PhD, MSE, Charles P. Semba, MD Ophthalmology Volume 121, Issue 2, Pages 475-483 (February 2014) DOI: 10.1016/j.ophtha.2013.09.015 Copyright © 2014 American Academy of Ophthalmology Terms and Conditions

Figure 1 Corneal fluorescein staining score in a study of lifitegrast compared with placebo for dry eye disease. Results for the inferior, superior, central, and total corneal regions (Ora scale) using mean change from baseline to day 84 analysis (*2-sided t test). LIF = lifitegrast; ODS = ocular discomfort score; SE = standard error. Ophthalmology 2014 121, 475-483DOI: (10.1016/j.ophtha.2013.09.015) Copyright © 2014 American Academy of Ophthalmology Terms and Conditions

Figure 2 Conjunctival lissamine staining score in a study of lifitegrast compared with placebo for dry eye disease. Results for nasal and total conjunctival regions (Ora scale) using mean change from baseline analysis (*2-sided t test, §Wilcoxon rank-sum test). LIF = lifitegrast; SE = standard error. Ophthalmology 2014 121, 475-483DOI: (10.1016/j.ophtha.2013.09.015) Copyright © 2014 American Academy of Ophthalmology Terms and Conditions

Figure 3 Key symptom scores in a study of lifitegrast compared with placebo for dry eye disease. The ocular discomfort zone (Ora scale; left) and Eye Dryness score (visual analog scale, right) at all visits (*2-sided t test). LIF = lifitegrast; SE = standard error. Ophthalmology 2014 121, 475-483DOI: (10.1016/j.ophtha.2013.09.015) Copyright © 2014 American Academy of Ophthalmology Terms and Conditions