Children Hospital “ Sor María Ludovica” La Plata - Argentina Relationship between IGF-1 levels at 32nd. and 34th. weeks of conceptional age and ROP Threshold Stage.” Children Hospital “ Sor María Ludovica” La Plata - Argentina

Authors: Ophtahalmolgist) María Marta Galán Md Vanina Schbibb Md Md. ( Neonatologist), Gabriel Carresane Md Silvina Gonzalez Md Biochemist Jorgelina Patín Andrea Fournier Statistics Lic. Sebastián Ferrero

– Development of inmature retinal vessels – Avascular retina at birth – Development of inmature retinal vessels – High and/or fluctuating tissue O2 – Abnormal chemical/hormonal signals

Objective To relate the variations in IGF-1 serum levels between the 32nd. and 34th. weeks of Gestational Age with Threshold ROP

MATERIAL AND METHOD July 2005/ March 2006 30 premature patients Without ocular malformations < 32 weeks of gestational age ( Capurro- Dubowitz) IGF-1 serum level with IRMA kit en ng/ml At 32nd. and 34th. weeks First cerebral ultrasound at third day

Screening for ROP completed according to Cryo-ROP Definitions • Threshold disease (current treatment indication): Any stage in Zone I with Plus Stage 3 extending over =5 contiguous or 8 non-contiguous clock hours in conjunction plus disease in Zone II Plus Disease“: Dilated vessels and tortuositas

National Guidelines for O2saturation to prematures from the National Health Ministery, June 2044 Approved by the Ethic Committee Consent obtained from parents Chi –square test and Yate’s correction

Results 30 prematures BW 1067 gr (630-1620) GA 29 w (26-31) Oxygen 20 days (2-64) CSN damage 12

BW 1093(680/1610) grs 919(630/1620)grs 0.15 GA 29.2 ( 26/31)W No Threshold n=24 Threshold n=6 p= BW 1093(680/1610) grs 919(630/1620)grs 0.15 GA 29.2 ( 26/31)W 28.6 ( 26/31)W 0.28 O days 15.5 (2/45) 20.1( 5/64) 0.24 CSN damage 7 5 % viariation IGF-1 7 ( -10.3/17.9) 57 (12.8/84) 0.003

Two samples Demographical homogenous population Attempting to relate the variations of IGF-1 with threshold ROP In preclinic stage Before phase 2 onset

G. E. Quinn, M.D., M.S.C.E.

Conclusion These results may suggest that the low increasing percentage of serum IGF-I concentrations between 32nd. and 34th. weeks of GA in prematures would be associated with later development of threshold ROP. Further studies would be needed to support this hypothesis.

Cathedral from La Plata: a jewell of the neogothic in Latin America Gratefulness for: IDIP (MS/CIC-PBA) Bernadotte Foundation Muchas gracias Cathedral from La Plata: a jewell of the neogothic in Latin America

% variation between the first and second sample Threshold n=6 Lower threshold n=24 p= 0.003