Formative Test

Q1- Anti-lipid drug that usually causes cutaneous vasodilation after each dose when the drug is started A- gemfibrozil      B- niacin      c- cholestyramine d-  clofibrate    e-  lovastatin

A- clofibrate B- gemfibrozil C- cholestyramine D- pravastatin Q2- Antilipidemic drug most likely to reduce serum digoxin levels: A- clofibrate   B- gemfibrozil C- cholestyramine D- pravastatin E- niacin

Q3- 54-year-old woman with severe hypercholesterolemia is to be treated with a combination of niacin and atorvastatin. With this drug combination, it is important that the patient be monitored closely for signs of:- (A) Agranulocytosis (B) Gallstones (C) Lactic acidosis (D) Myopathy (E) Thyrotoxicosis

Q4-A 35year- old male with markedly elevated plasma triglycerides and LDL levels is treated with gemfibrozil. What is the mechanism of action of gemfibrozil? Sequestration of bile acids Decreased hepatic secretion of VLDL Increased lipoprotein lipase activity Inhibition of HMG-CoA reductase Decreased oxidation of plasma lipids

Q5-Which of the following drugs recommended for the lowering of blood cholesterol inhibits the synthesis by blocking 3-hydroxy-3-methylglutaryl coenzyme A reductase? Gemfibrozil Niacin Ezetimibe Atorvastatin Cholestyramine