The hypothalamus controls the pituitary gland both directly and indirectly through hormone- releasing neurons. Neurons in the magnocellular neuroendocrine.

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The hypothalamus controls the pituitary gland both directly and indirectly through hormone- releasing neurons. Neurons in the magnocellular neuroendocrine system (blue) send their axons directly to the posterior pituitary (neurohypophysis) where they release the peptides vasopressin and oxytocin into the general circulation. Neurons in the parvicellular neuroendocrine system (yellow) send their axons to a venous portal system in the median eminence and pituitary stalk. Long and short portal veins transport hypothalamic hormones (peptides and dopamine) to the anterior pituitary (adenohypophysis) where they bind to five classic types of endocrine cells and influence the release of their hormones (see Figure 47–11). The output of neuroendocrine neurons is regulated in large part by inputs from other regions of the brain. (Reproduced, with permission, from Reichlin 1978; and Gay 1972.) Source: The Autonomic Motor System and the Hypothalamus, Principles of Neural Science, Fifth Editon Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available at: https://neurology.mhmedical.com/DownloadImage.aspx?image=/data/books/1049/kan_ch47_f012.png&sec=59145409&BookID=1049&ChapterSecID=59138679&imagename= Accessed: December 14, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved