Volume 12, Issue 3, Pages (March 2012)

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Volume 12, Issue 3, Pages 257-264 (March 2012) Effect of short-term unloading on T2 relaxation time in the lumbar intervertebral disc— in vivo magnetic resonance imaging study at 3.0 tesla David Stelzeneder, MD, Balázs K. Kovács, MD, Sabine Goed, MD, Goetz H. Welsch, MD, Clemens Hirschfeld, MD, Tatjana Paternostro- Sluga, MD, Klaus M. Friedrich, MD, Tallal C. Mamisch, MD, Siegfried Trattnig, MD The Spine Journal Volume 12, Issue 3, Pages 257-264 (March 2012) DOI: 10.1016/j.spinee.2012.02.001 Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 1 T2-weighted sagittal fast spin echo image is compared with a color-coded T2 map of intervertebral discs with regions of interest (ROIs). Each ROI measured 20% of the midline disc diameter in the sagittal plane. Region of interest 1 is interpreted as the anterior annulus fibrosus (AF), ROI 5 as the posterior AF, and ROIs 2 to 4 as the nucleus pulposus. The ROI numbering is illustrated in the L4/L5 disc. The Spine Journal 2012 12, 257-264DOI: (10.1016/j.spinee.2012.02.001) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 2 Change in T2 values in milliseconds in different compartments of the disc from early to late unloading in the supine position. Each bar represents the mean of T2 changes in one 20% ROI from the anterior (blue) to the posterior AF (yellow). Error bars represent 95% confidence intervals. ROI, region of interest; AF, annulus fibrosus; NP, nucleus pulposus. The Spine Journal 2012 12, 257-264DOI: (10.1016/j.spinee.2012.02.001) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 3 T2 value changes in discs with low and high NP T2 values (lowest and highest third). Error bars represent 95% confidence intervals. ROI, region of interest; AF, annulus fibrosus; NP, nucleus pulposus. The Spine Journal 2012 12, 257-264DOI: (10.1016/j.spinee.2012.02.001) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 4 T2 value changes in patients investigated in the morning (8 am to 12 pm) and afternoon (1–6 pm). Error bars represent 95% confidence intervals. ROI, region of interest; AF, annulus fibrosus, NP, nucleus pulposus. The Spine Journal 2012 12, 257-264DOI: (10.1016/j.spinee.2012.02.001) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 5 T2 value changes in patients with high and low LLAs (lowest and highest third). Error bars represent 95% confidence intervals. ROI, region of interest; LLA, lumbar lordosis angle; AF, annulus fibrosus; NP, nucleus pulposus. The Spine Journal 2012 12, 257-264DOI: (10.1016/j.spinee.2012.02.001) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 6 Scatter/dot plot of the time of investigation and T2 value changes in the posterior annulus fibrosus. Pearson correlation analysis shows a moderate association. The Spine Journal 2012 12, 257-264DOI: (10.1016/j.spinee.2012.02.001) Copyright © 2012 Elsevier Inc. Terms and Conditions