Fig. 1. Fetal GSIS. Fetal plasma glucose (A) and insulin (B) concentrations determined for the in vivo GSIS study are presented as the mean ± sem for control.

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Fig. 1. Fetal GSIS. Fetal plasma glucose (A) and insulin (B) concentrations determined for the in vivo GSIS study are presented as the mean ± sem for control (n = 13) and IUGR (n = 7) fetuses. Administration of the glucose bolus and infusion were started at 0 min. Statistical analyses are presented in Results. From: Attenuated Insulin Release and Storage in Fetal Sheep Pancreatic Islets with Intrauterine Growth Restriction Endocrinology. 2006;147(3):1488-1497. doi:10.1210/en.2005-0900 Endocrinology | Copyright © 2006 by The Endocrine Society

Fig. 5. Fetal sheep islet glucose utilization and oxidation Fig. 5. Fetal sheep islet glucose utilization and oxidation. The rate of glucose utilization (A) and rate of glucose oxidation (B) for control (white bars, n = 7) and IUGR (black bars, n = 7) fetal islets were determined for four or more replicates at 1.1 mmol/liter glucose (normal ovine fetal glucose concentration) or 11.1 mmol/liter glucose (stimulated concentrations). A significant reduction (*, P < 0.05) in the rate of glucose oxidation was found for IUGR islets at 11.1 mmol/liter glucose, but no difference was identified at normal glucose concentrations. From: Attenuated Insulin Release and Storage in Fetal Sheep Pancreatic Islets with Intrauterine Growth Restriction Endocrinology. 2006;147(3):1488-1497. doi:10.1210/en.2005-0900 Endocrinology | Copyright © 2006 by The Endocrine Society

Fig. 4. Comparison of control and IUGR islets Fig. 4. Comparison of control and IUGR islets. Fetal sheep islets isolated from control (white bars, n = 9) and IUGR (black bars, n = 7) treatment groups were evaluated for the fraction of insulin released (A), insulin content (B), and nanograms of insulin secreted per islet (C). *, P < 0.05, differences between treatment groups for the incubation condition (A and C) and difference between control and IUGR fetal islets insulin content (B). From: Attenuated Insulin Release and Storage in Fetal Sheep Pancreatic Islets with Intrauterine Growth Restriction Endocrinology. 2006;147(3):1488-1497. doi:10.1210/en.2005-0900 Endocrinology | Copyright © 2006 by The Endocrine Society

Fig. 3. Norepinephrine vs. oxygen content in fetal sheep Fig. 3. Norepinephrine vs. oxygen content in fetal sheep. Comparison of fetal plasma norepinephrine (pg/ml, y-axis) and fetal blood oxygen content (mmol/liter, x-axis) are presented for control (□, n = 9) and IUGR (•, n = 7) fetuses. The regression line (y = −1007.3x + 4117.3; R<sup>2</sup> = 0.84) for all fetuses is depicted on the graph. From: Attenuated Insulin Release and Storage in Fetal Sheep Pancreatic Islets with Intrauterine Growth Restriction Endocrinology. 2006;147(3):1488-1497. doi:10.1210/en.2005-0900 Endocrinology | Copyright © 2006 by The Endocrine Society

Fig. 2. ASIS. Mean fetal plasma insulin concentrations (ng/ml, y-axis) after the arginine bolus (minutes, x-axis) are presented for control (n = 13) and IUGR (n = 7) fetuses. From: Attenuated Insulin Release and Storage in Fetal Sheep Pancreatic Islets with Intrauterine Growth Restriction Endocrinology. 2006;147(3):1488-1497. doi:10.1210/en.2005-0900 Endocrinology | Copyright © 2006 by The Endocrine Society