Mastectomy trends for early-stage breast cancer: A report from the EUSOMA multi- institutional European database  Carlos A. Garcia-Etienne, Mariano Tomatis,

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Mastectomy trends for early-stage breast cancer: A report from the EUSOMA multi- institutional European database  Carlos A. Garcia-Etienne, Mariano Tomatis, Joerg Heil, Kay Friedrichs, Rolf Kreienberg, Andreas Denk, Marion Kiechle, Fatemeh Lorenz-Salehi, Rainer Kimmig, Günter Emons, Mahmoud Danaei, Volker Heyl, Uwe Heindrichs, Christoph J. Rageth, Wolfgang Janni, Lorenza Marotti, Marco Rosselli del Turco, Antonio Ponti  European Journal of Cancer  Volume 48, Issue 13, Pages 1947-1956 (September 2012) DOI: 10.1016/j.ejca.2012.03.008 Copyright © 2012 Elsevier Ltd Terms and Conditions

Fig. 1 Sequence of attempted initial surgery and definitive surgery for the 15,369 cases. BCS: breast-conserving surgery. European Journal of Cancer 2012 48, 1947-1956DOI: (10.1016/j.ejca.2012.03.008) Copyright © 2012 Elsevier Ltd Terms and Conditions

Fig. 2 Mastectomy rates for attempted (initial) and definitive surgery by year from 2003 to 2010 from 13 Breast Units. ∗Crude rates. European Journal of Cancer 2012 48, 1947-1956DOI: (10.1016/j.ejca.2012.03.008) Copyright © 2012 Elsevier Ltd Terms and Conditions

Fig. 3 Mastectomy trend for definitive surgery from 2003 to 2010 for 13 Breast Units. ∗Adjusted for age group, pT, pN, tumour histology and grade, disease extent, ER/PR status and Breast Unit. 2003–2005 (p=0.181); 2005–2010 (p=0.003). European Journal of Cancer 2012 48, 1947-1956DOI: (10.1016/j.ejca.2012.03.008) Copyright © 2012 Elsevier Ltd Terms and Conditions

Fig. 4 Crude mastectomy rates from previous studies and from the eusomaDB. Moffit CC: Moffitt Cancer Center; SEER: Surveillance, Epidemiology, and End Results registry; GWU: George Washington University; eusomaDB: EUSOMA Database. European Journal of Cancer 2012 48, 1947-1956DOI: (10.1016/j.ejca.2012.03.008) Copyright © 2012 Elsevier Ltd Terms and Conditions