Figure 1. Serum B-ALP levels in normal male (•) and female (○) children as a function of age. Serum B-ALP levels were increased during infancy and puberty.

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Figure 1. Serum B-ALP levels in normal male (•) and female (○) children as a function of age. Serum B-ALP levels were increased during infancy and puberty. Females had their peak serum B-ALP levels during puberty about 2 yr earlier than males. Values are group mean ± sd. Serum Bone Alkaline Phosphatase Isoenzyme Levels in Normal Children and Children with Growth Hormone (GH) Deficiency: A Potential Marker for Bone Formation and Response to GH Therapy1 J Clin Endocrinol Metab. 1997;82(7):2056-2061. doi:10.1210/jcem.82.7.4081 J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society

Figure 2. Serum B-ALP levels in normal prepubertal and pubertal children vs. pubertal stage of maturation. A, Serum B-ALP levels in normal prepubertal and pubertal children vs. testicular volume (in 62 males; <4 mL, prepuberty;> 12 mL, adult stage). Serum B-ALP levels vs. stage of breast development (in 39 females) (A) and stage of pubic hair development (in 62 males and 39 females) (C) according to Tanner. Highest serum B-ALP level was observed in midpuberty (stage 3). Values are group mean ± sd, and significance was determined by comparison with prepubertal values: *, P < 0.05. Serum Bone Alkaline Phosphatase Isoenzyme Levels in Normal Children and Children with Growth Hormone (GH) Deficiency: A Potential Marker for Bone Formation and Response to GH Therapy1 J Clin Endocrinol Metab. 1997;82(7):2056-2061. doi:10.1210/jcem.82.7.4081 J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society

Figure 3. Correlations of serum levels of B-ALP and PICP and osteocalcin in normal male (•) and female (○) children. A significant positive correlation was found between serum levels of B-ALP and PICP (r = 0.447, P < 0.0001) and osteocalcin (r = 0.433, P < 0.0001). Serum Bone Alkaline Phosphatase Isoenzyme Levels in Normal Children and Children with Growth Hormone (GH) Deficiency: A Potential Marker for Bone Formation and Response to GH Therapy1 J Clin Endocrinol Metab. 1997;82(7):2056-2061. doi:10.1210/jcem.82.7.4081 J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society

Figure 4. Serum B-ALP response to GH administration Figure 4. Serum B-ALP response to GH administration. Procedures are described in Subjects and Methods. Serum levels of B-ALP increased significantly during GH administration. Values are group mean ± sd, and significance was determined by comparison with pretreatment values: *, P < 0.005. Serum Bone Alkaline Phosphatase Isoenzyme Levels in Normal Children and Children with Growth Hormone (GH) Deficiency: A Potential Marker for Bone Formation and Response to GH Therapy1 J Clin Endocrinol Metab. 1997;82(7):2056-2061. doi:10.1210/jcem.82.7.4081 J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society

Figure 5. Relationship between percent increase in serum B-ALP levels after 3 months of GH treatment and improvement in height sd scores or height velocity sd scores after 1 yr of GH treatment. Percent increases in serum B-ALP levels after 3 months of GH treatment were significantly correlated with increases of height sd score (Δ height sd score; r = 0.531, P < 0.05) or height velocity sd score (Δ height velocity sd score; r = 0.608, P < 0.01) after 1 yr of GH treatment. Serum Bone Alkaline Phosphatase Isoenzyme Levels in Normal Children and Children with Growth Hormone (GH) Deficiency: A Potential Marker for Bone Formation and Response to GH Therapy1 J Clin Endocrinol Metab. 1997;82(7):2056-2061. doi:10.1210/jcem.82.7.4081 J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society

Figure 6. Relationship between improvement in B-ALP sd score and that in BMD sd score after 1 yr of GH treatment. Procedure is described in Subjects and Methods. Increases in serum B-ALP sd score (Δ B-ALP sd score) were significantly correlated with those in BMD sd score (Δ BMD sd score) after 1 yr of GH treatment (r = 0.663, P < 0.005). Serum Bone Alkaline Phosphatase Isoenzyme Levels in Normal Children and Children with Growth Hormone (GH) Deficiency: A Potential Marker for Bone Formation and Response to GH Therapy1 J Clin Endocrinol Metab. 1997;82(7):2056-2061. doi:10.1210/jcem.82.7.4081 J Clin Endocrinol Metab | Copyright © 1997 by The Endocrine Society