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Fig. 1. Distribution of tetracycline labels (A) and MS/BS (B) in the TPTD and ZOL acid groups: values are medians (interquartile range). Representative.

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Presentation on theme: "Fig. 1. Distribution of tetracycline labels (A) and MS/BS (B) in the TPTD and ZOL acid groups: values are medians (interquartile range). Representative."— Presentation transcript:

1 Fig. 1. Distribution of tetracycline labels (A) and MS/BS (B) in the TPTD and ZOL acid groups: values are medians (interquartile range). Representative photomicrograph of tetracycline labels in cancellous bone from the ZOL (MS/BS = 0.20%) (C) and TPTD (MS/BS = 5.38%) (D) groups. From: Skeletal Histomorphometry in Subjects on Teriparatide or Zoledronic Acid Therapy (SHOTZ) Study: A Randomized Controlled Trial J Clin Endocrinol Metab. 2012;97(8): doi: /jc J Clin Endocrinol Metab | Copyright © 2012 by The Endocrine Society

2 Fig. 2. MAR in the TPTD and ZOL groups: values are medians (interquartile range). MAR was calculated in four different ways. MAR 1, Double labels only. MAR 2, Double labels, single labels: MAR = 0.3 μm/d, no labels: MAR = zero. MAR 3, Double labels, single labels: MAR = missing, no labels: MAR = zero. MAR 4, Double labels, single labels: MAR = 0.3 μm/d, no labels: MAR = missing. From: Skeletal Histomorphometry in Subjects on Teriparatide or Zoledronic Acid Therapy (SHOTZ) Study: A Randomized Controlled Trial J Clin Endocrinol Metab. 2012;97(8): doi: /jc J Clin Endocrinol Metab | Copyright © 2012 by The Endocrine Society

3 Fig. 3. Percentage change from baseline to month 12 (mean ± se) in serum P1NP and CTX for ZOL (A) and TPTD (B) (P < for all between-group comparisons for change from baseline). C, Correlation of P1NP and MS/BS at month 6. From: Skeletal Histomorphometry in Subjects on Teriparatide or Zoledronic Acid Therapy (SHOTZ) Study: A Randomized Controlled Trial J Clin Endocrinol Metab. 2012;97(8): doi: /jc J Clin Endocrinol Metab | Copyright © 2012 by The Endocrine Society

4 Fig. 4. Spider plots of dynamic (A) and static histomorphometric (B) parameters in the TPTD and ZOL groups: values are medians based on MAR 1 analyses. From: Skeletal Histomorphometry in Subjects on Teriparatide or Zoledronic Acid Therapy (SHOTZ) Study: A Randomized Controlled Trial J Clin Endocrinol Metab. 2012;97(8): doi: /jc J Clin Endocrinol Metab | Copyright © 2012 by The Endocrine Society

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