Erika Kajdácsi, MSc, Péter K

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Endothelial cell activation during edematous attacks of hereditary angioedema types I and II Erika Kajdácsi, MSc, Péter K. Jani, MSc, Dorottya Csuka, PhD, Lilian Ágnes Varga, PhD, Zoltán Prohászka, MD, DSc, Henriette Farkas, MD, DSc, László Cervenak, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 6, Pages 1686-1691 (June 2014) DOI: 10.1016/j.jaci.2013.12.1072 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Endothelial marker levels of patients with HAE between and during attacks. VWF:Ag (A), VWF:CBA (B), sE-selectin (C), and ET-1 (D) were compared. The Wilcoxon matched pairs test (VWF:Ag, VWF:CBA, and sE-selectin) or the parametric paired t test (ET-1) was used for comparisons. P values and the direction of change are indicated (n = 18). Normal ranges are shown in Table I. Journal of Allergy and Clinical Immunology 2014 133, 1686-1691DOI: (10.1016/j.jaci.2013.12.1072) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Comparison of endothelial marker levels in nonsmoking subgroups of patients with HAE (n = 13). Inter-attack and during-attack samples were compared for VWF:Ag (A), VWF:CBA (B), sE-selectin (C), and ET-1 (D). The Wilcoxon matched pairs test (VWF:CBA, sE-selectin, and ET-1) or the parametric paired t test (VWF:Ag) was used for comparison. P values are indicated. Normal ranges are shown in Table I. Journal of Allergy and Clinical Immunology 2014 133, 1686-1691DOI: (10.1016/j.jaci.2013.12.1072) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Comparison of endothelial marker levels in danazol-treated and nontreated subgroups of patients with HAE. Inter-attack (IA) and during-attack (DA) samples were compared for VWF:Ag (A) and VWF:CBA (B). The Wilcoxon matched pairs test was used for comparison in both danazol-treated (n = 7) and non–danazol-treated (n = 9) subgroups. P values are indicated. Normal ranges are shown in Table I. Journal of Allergy and Clinical Immunology 2014 133, 1686-1691DOI: (10.1016/j.jaci.2013.12.1072) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Distribution of EC markers during multiple attacks in the same patients with HAE. VWF:Ag (A), VWF:CBA (B), sE-selectin (C), and ET-1 (D) were assessed in 8 patients with more than 1 during-attack sample. Each during-attack (DA) value was divided by the corresponding inter-attack (IA) value, and these ratios were plotted as open circles. The medians of the ratios are presented as a solid line. The values under the dotted line represent decreased levels, whereas those above the dotted line correspond to increased EC marker levels. Journal of Allergy and Clinical Immunology 2014 133, 1686-1691DOI: (10.1016/j.jaci.2013.12.1072) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions