Lecture 3 Dr.Narmin Hussen 15 Dopamine Lecture 3 Dr.Narmin Hussen

Dopamine Some of its notable functions are in: movement memory pleasurable reward behavior and cognition Attention inhibition of prolactin production sleep mood learning

Dopaminergic Pathways

Synthesis of Dopamine precursor of norepinephrine and epinephrine.

Dopamine Receptors DA receptors are divided into five subtypes, D1 to D5

Dopamine Metabolism

Parkinson Disease PD is a progressive neurodegenerative, dopamine deficiency disorder

video-1493659367.mp4

Symptoms of Parkinson's disease Slowness of movement and Shuffling walk Tremor (shaking) Muscle rigidity (Stiffness) Muffled speech

Risk factor Age Genetic factors Head Injury Environmental factors Gender

Diagnosis of Parkinson's disease Clinical features Brain scans(CT or MRI)

Treatment Levodopa:

Levodopa/Carbidopa (sinemet):

MAO-B Inhibitors: 1(R)-aminoindan, 3-hydroxy-N-propargyl-1-aminoindan, and 3-hydroxy-1-aminoindan a selective irreversible inhibitor of MAO-B

Dopamine Agonists DA agonists are classified into: Ergot derivatives (pergolide, cabergoline, and bromocriptine) withdrawn from the market.

Nonergot derivatives (apomorphine, pramipexole, ropinirole, and rotigotine). , 4-carboxymethylindolin-2-one N-despropylrotigotine and N-desthienylethyl rotigotine

COMT Inhibitors: only inhibits peripheral COMT Tolcapone is a selective and reversible inhibitor of COMT in the CNS and periphery Entacapone does not penetrate the BBB