Nodular lymphocyte-predominant Hodgkin lymphoma. A

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Nodular lymphocyte-predominant Hodgkin lymphoma. A Nodular lymphocyte-predominant Hodgkin lymphoma. A. At low-power magnification, the neoplasm is vaguely nodular. B. At high-power magnification, large lymphocytic and histiocytic (LH) cells, resembling popped kernels of corn, are identified in a background of reactive lymphocytes and histiocytes. C and D. Immunohistochemical stain for CD20. C. At low-power magnification, this immunostain highlights the nodular pattern and shows numerous B cells in the nodules. D. At high-power magnification, large LH cells and small reactive B cells are positive for CD20. E. Immunohistochemical stain for CD3. Scattered small reactive T cells are present and focally surround the LH cells (so-called rosetting). Source: Hodgkin Lymphoma, The MD Anderson Manual of Medical Oncology, 3e Citation: Kantarjian HM, Wolff RA. The MD Anderson Manual of Medical Oncology, 3e; 2016 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/1772/kantmmo3_ch10_f001c.png&sec=121897527&BookID=1772&ChapterSecID=121897510&imagename= Accessed: November 05, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved