Failure to Downregulate the Epithelial Sodium Channel Causes Salt Sensitivity in Hsd11b2 Heterozygote MiceNovelty and Significance by Eilidh Craigie, Louise.

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Failure to Downregulate the Epithelial Sodium Channel Causes Salt Sensitivity in Hsd11b2 Heterozygote MiceNovelty and Significance by Eilidh Craigie, Louise C. Evans, John J. Mullins, and Matthew A. Bailey Hypertension Volume 60(3):684-690 August 15, 2012 Copyright © American Heart Association, Inc. All rights reserved.

A, Arterial blood pressure, (B) glomerular filtration rate, and (C) renal blood flow in Hsd11b2+/+ (☐) and Hsd11b2+/− (▩) mice after 3 weeks on low-sodium (LS; n=7 and 8), standard-sodium (SS; n=8 and 8), or high-sodium (HS; n=9 and 11) diet. A, Arterial blood pressure, (B) glomerular filtration rate, and (C) renal blood flow in Hsd11b2+/+ (☐) and Hsd11b2+/− (▩) mice after 3 weeks on low-sodium (LS; n=7 and 8), standard-sodium (SS; n=8 and 8), or high-sodium (HS; n=9 and 11) diet. Data are mean±SEM. Comparisons were made using ANOVA with Bonferroni post hoc test. *P<0.05; **P<0.01. Eilidh Craigie et al. Hypertension. 2012;60:684-690 Copyright © American Heart Association, Inc. All rights reserved.

A, Fractional sodium excretion, (B) fractional potassium excretion, (C) amiloride-sensitive sodium reabsorption (ΔamilorideNa), and (D) amiloride sensitive potassium secretion (ΔamilorideK) in Hsd11b2+/+ (☐) and Hsd11b2+/− (▩) mice after 3 weeks on low-sodium (LS; n=7 and 8), standard-sodium (SS; n=8 and 8), or high-sodium (HS; n=9 and 11) diet. A, Fractional sodium excretion, (B) fractional potassium excretion, (C) amiloride-sensitive sodium reabsorption (ΔamilorideNa), and (D) amiloride sensitive potassium secretion (ΔamilorideK) in Hsd11b2+/+ (☐) and Hsd11b2+/− (▩) mice after 3 weeks on low-sodium (LS; n=7 and 8), standard-sodium (SS; n=8 and 8), or high-sodium (HS; n=9 and 11) diet. Data are mean±SEM. Comparisons were made using ANOVA with Bonferroni post hoc test. *P<0.05; **P<0.01. Eilidh Craigie et al. Hypertension. 2012;60:684-690 Copyright © American Heart Association, Inc. All rights reserved.

A, Arterial blood pressure, (B) renal blood flow, (C) fractional sodium excretion, and (D) amiloride-sensitive sodium reabsorption (ΔamilorideNa) in Hsd11b2+/+ (☐) and Hsd11b2+/− (▩) mice after 3 weeks on a high-sodium (HS) diet or with HS diet accompany by either benzamil (Benz; n=6 and 7), spironolactone (Spiro; n=6 and 8), or RU486 treatment (n=9 and 10). A, Arterial blood pressure, (B) renal blood flow, (C) fractional sodium excretion, and (D) amiloride-sensitive sodium reabsorption (ΔamilorideNa) in Hsd11b2+/+ (☐) and Hsd11b2+/− (▩) mice after 3 weeks on a high-sodium (HS) diet or with HS diet accompany by either benzamil (Benz; n=6 and 7), spironolactone (Spiro; n=6 and 8), or RU486 treatment (n=9 and 10). Data are mean±SEM. Comparisons were made using ANOVA with Bonferroni post hoc test. *P<0.05; **P<0.01. Eilidh Craigie et al. Hypertension. 2012;60:684-690 Copyright © American Heart Association, Inc. All rights reserved.