Oncogene activation Transcription DNA damage MDM2 CDKN2A MDM4 p53 ATR

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Oncogene activation Transcription DNA damage MDM2 CDKN2A MDM4 p53 ATR miR-221/222; miR-26ab/1297; miR-208/208ab; miR-499/499-5p; miR-10; miR-194; miR-24 MDM2 CDKN2A miR-9; miR-128; miR-365; miR-125/351 miR-130/301; miR-19; miR-7/7ab; miR-183; miR-191; miR-216/216b; miR-17-5p/20/93.mr/106/519.d; miR-199/199-5p; miR-122; miR-137; miR-129/129-5p; miR-10 MDM4 miR-150; miR-27ab; let-7/98; miR-125/351; miR-338/338-3p; miR-143; miR-19; miR-148/152; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-218; miR-22; miR-128; miR-219/219-5p; miR-24; miR-141/200a; miR-25/32/92/92ab/363/367; miR-223 p53 Transcription ATR CHEK1 CHEK2 miR-383; miR-146; miR-132/212 miR-15/16/195/424/497; miR-7/7ab; miR-503 ATM DNA damage miR-181; miR-26ab/1297; miR-18ab; miR-203; miR-193ab; miR-141/200a; miR-217; miR-106/302; miR-194; miR-383; miR-129/129-5p; miR-214/761; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-132/212; miR-143; miR-182; miR-208/208ab; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-101; miR-21/590-5p; miR-192/215 ;miR-338/338-3p; miR-499/499-5p; miR-10; miR-130/301; miR-375; miR-122; miR-221/222; miR-425/489; miR-17-5p/20/93.mr/106/519.d; miR-150; miR-103/107; miR-216/216a; miR-96/1271; miR-216/216b; miR-204/211; miR-24 Supplemental Figure 5. Overview of p53 signaling. Summary of p53 signaling and predicted miRNA interactions. miRNAs that were described to be downregulated in bladder cancer are highlighted in green, while upregulated miRNAs are highlighted in red; all other potential interactions are highlighted in black. Target interactions were predicted with TargetScan 5.1. miRNAs presented in this figure are all highly conserved among vertebrates; for a list of other miRNAs see Supplement Table 6.