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© The Author(s) 2015. Published by Science and Education Publishing. Table 1. Clinical, immunological features, and outcome in patients with SLE and SMZL Case 1 (9) Case 2 (8) Case 3 (1) Our case Age at SLE onset (year) Uns 66 72 Age at SMZL onset (year) 69 Delay (year) 7 3 Clinical features of SLE Alopecia, discoid lupus, polyarthritis, proteinuria, lymphopenia Polyarthritis, pleuropericarditis, lymphopenia Polyarthritis, pleural effusion, lymphopenia, hemolytic anemia, thrombocytopenia Malar rash, hemolytic anemia, thrombocytopenia, lymphopenia, proteinuria, pleural effusion immunological features Positive ANA Positive ANA (1/1000), positive anti-DNA Positive ANA (1/32 000), positive anti- platelet antibodies, Positive ANA (1/1280) Clinical presence of lymphoma Hepatosplenomegaly, lymph nodes, monoclonal gammapathy (Ig G kappa) General symptoms, splenomegaly, lymph nodes, monoclonal gammapathy (Ig G kappa) General symptoms, hepatosplenomegaly, lymph nodes, monoclonal gammapathy (Ig M kappa) Treatment Splenectomy + chemotherapy (cyclophosphamide, adriamycine, vincristine, and prednisone) Rituximab+prednisone Outcome Favorable Decline (months) 6 12 ANA: antinuclear antibodies, Uns: unspecified Bel Feki N et al. Systemic Lupus Erythematosus Revealing Splenic Marginal Zone Lymphoma. A Case Report. American Journal of Medical Case Reports, 2015, Vol. 3, No. 2, 40-41. doi:10.12691/ajmcr-3-2-6 © The Author(s) 2015. Published by Science and Education Publishing.