Presented By Antoni Ribas at 2014 ASCO Annual Meeting

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Presentation transcript:

Presented By Antoni Ribas at 2014 ASCO Annual Meeting Efficacy and Safety of the Anti-PD-1 <br />Monoclonal Antibody Pembrolizumab (MK-3475) in 411 Patients With Melanoma Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Presented By Antoni Ribas at 2014 ASCO Annual Meeting Disclosures Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Pembrolizumab and Available Clinical Data: KEYNOTE-001 (NCT01295827) Presented By Antoni Ribas at 2014 ASCO Annual Meeting

411 Patients in Melanoma Expansion Cohorts: KEYNOTE-001 Presented By Antoni Ribas at 2014 ASCO Annual Meeting

KEYNOTE-001 Eligibility Criteria Presented By Antoni Ribas at 2014 ASCO Annual Meeting

KEYNOTE-001 Eligibility Criteria Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Baseline Characteristics (1) Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Baseline Characteristics (2) Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Presented By Antoni Ribas at 2014 ASCO Annual Meeting Summary of Exposurea and <br />Treatment-Related AEs by Prior IPI Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Treatment-Related AEs With Incidence >5% Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Presented By Antoni Ribas at 2014 ASCO Annual Meeting Immune-Mediated AEs Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Presented By Antoni Ribas at 2014 ASCO Annual Meeting Maximum Percent Change from Baseline in Tumor Sizea (Central Review, RECIST v1.1) Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Presented By Antoni Ribas at 2014 ASCO Annual Meeting Maximum Percent Change from Baseline in Tumor Sizea (Central Review, irRC) Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Confirmed ORR in Subgroups (Central Review, RECIST v1.1) Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Antitumor Activity by Prior Ipilimumab and Pembrolizumab Dose/Schedule Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Presented By Antoni Ribas at 2014 ASCO Annual Meeting Slide 16 Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Presented By Antoni Ribas at 2014 ASCO Annual Meeting Kaplan-Meier Estimate of PFS per RECIST 1.1, Independent Central Review Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Kaplan-Meier Estimate of Overall Survival Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Presented By Antoni Ribas at 2014 ASCO Annual Meeting Summary Presented By Antoni Ribas at 2014 ASCO Annual Meeting

Presented By Antoni Ribas at 2014 ASCO Annual Meeting Acknowledgments Presented By Antoni Ribas at 2014 ASCO Annual Meeting