Copyright © 2008 American Medical Association. All rights reserved. From: Better Outcomes for Patients Treated at Hospitals That Participate in Clinical Trials Arch Intern Med. 2008;168(6):657-662. doi:10.1001/archinternmed.2007.124 Figure Legend: Adherence to evidence-based guideline recommendations at 494 CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the American College of Cardiology/American Heart Association Guidelines) hospitals, according to tertiles of hospital-level clinical trial participation. Tertiles of hospital-level trial participation include no participation tertile (0% of patients enrolled in trials) vs low trial participation tertile (1.0% enrolled [interquartile range, 0.5%-1.4%]) vs high trial participation tertile (4.9% enrolled [interquartile range, 3.5%-9.7%]). P = .36 for the difference between the no- and low-enrollment groups, P = .01 for the difference between the no- and high-enrollment groups, and P = .03 for the difference between the low- and high-enrollment groups. P values are weighted by the number of patients at each site and adjusted for all hospital-level variables presented in Table 1 (see the “Analysis” subsection of the “Methods” section). Date of download: 10/29/2017 Copyright © 2008 American Medical Association. All rights reserved.

Copyright © 2008 American Medical Association. All rights reserved. From: Better Outcomes for Patients Treated at Hospitals That Participate in Clinical Trials Arch Intern Med. 2008;168(6):657-662. doi:10.1001/archinternmed.2007.124 Figure Legend: Short-term mortality in 174 062 patients with acute coronary syndrome treated at 494 CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the American College of Cardiology/American Heart Association Guidelines) hospitals, according to tertiles of hospital-level clinical trial participation. Tertiles of hospital-level trial participation include no participation tertile (0% of patients enrolled in trials) vs low trial participation (1.0% enrolled [interquartile range, 0.5%-1.4%]) vs high trial participation tertile (4.9% enrolled [interquartile range, 3.5%-9.7%]). P = .04 for the difference between the no- and low-enrollment groups, P = .003 for the difference between the no- and high-enrollment groups, and P = .06 for the difference between the low- and high-enrollment groups. P values are adjusted for all hospital- and patient-level variables presented in Table 1 and Table 2, respectively (see the “Analysis” subsection of the “Methods” section). Date of download: 10/29/2017 Copyright © 2008 American Medical Association. All rights reserved.