Steven Baroletti, PharmD, MBA, Shelley Hurwitz, PhD, Nicole A. S

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Presentation transcript:

Thrombosis in Suspected Heparin-induced Thrombocytopenia Occurs More Often with High Antibody Levels Steven Baroletti, PharmD, MBA, Shelley Hurwitz, PhD, Nicole A.S. Conti, PharmD, John Fanikos, RPh, MBA, Gregory Piazza, MD, Samuel Z. Goldhaber, MD The American Journal of Medicine Volume 125, Issue 1, Pages 44-49 (January 2012) DOI: 10.1016/j.amjmed.2011.06.025 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Association of anti-PF4/heparin antibody level with any arterial or venous thrombosis and pulmonary embolism. The proportion with any thrombosis by 30 days and the proportion with pulmonary embolism are shown as a function of anti-PF4/heparin antibody level. Increases in anti-PF4/heparin antibody level were significantly associated with greater proportions of any thrombosis and pulmonary embolism by 30 days. PE=pulmonary embolism; PF4=platelet factor 4; OD=optical density. The American Journal of Medicine 2012 125, 44-49DOI: (10.1016/j.amjmed.2011.06.025) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 2 Observed and predicted thrombosis proportion according to anti-PF4/heparin antibody level and 95% confidence band. CI=confidence interval; PF4=platelet factor 4. The American Journal of Medicine 2012 125, 44-49DOI: (10.1016/j.amjmed.2011.06.025) Copyright © 2012 Elsevier Inc. Terms and Conditions