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Effect of Folic Acid, with or without Other B Vitamins, on Cognitive Decline: Meta- Analysis of Randomized Trials  David S. Wald, MA, MRCP, MD, Anuradhani.

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Presentation on theme: "Effect of Folic Acid, with or without Other B Vitamins, on Cognitive Decline: Meta- Analysis of Randomized Trials  David S. Wald, MA, MRCP, MD, Anuradhani."— Presentation transcript:

1 Effect of Folic Acid, with or without Other B Vitamins, on Cognitive Decline: Meta- Analysis of Randomized Trials  David S. Wald, MA, MRCP, MD, Anuradhani Kasturiratne, MD, Mark Simmonds, PhD  The American Journal of Medicine  Volume 123, Issue 6, Pages e2 (June 2010) DOI: /j.amjmed Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 Standardized mean differences in cognitive function test scores (and 95% confidence intervals) between folic acid, with or without other B vitamins, and placebo groups for all tests within each randomized trial and pooled effect across all trials. CI=confidence interval; SMD=standardized mean difference. The American Journal of Medicine  , e2DOI: ( /j.amjmed ) Copyright © 2010 Elsevier Inc. Terms and Conditions

3 Figure 2 Standardized mean differences in cognitive function test scores (and 95% confidence intervals) between folic acid, with or without other B vitamins, and placebo groups according to category of cognitive function (each square represents 1 scored task within a cognitive function test for a randomized trial). The American Journal of Medicine  , e2DOI: ( /j.amjmed ) Copyright © 2010 Elsevier Inc. Terms and Conditions

4 Figure 3 Standardized mean differences and 95% confidence intervals in subgroups of randomized trials according to mean age of participants, treatment received, folic acid dose, and duration of treatment. CI=confidence interval; SMD=standardized mean difference. The American Journal of Medicine  , e2DOI: ( /j.amjmed ) Copyright © 2010 Elsevier Inc. Terms and Conditions


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