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Chapter 68 Chapter 68 Fracture Risk Assessment: The Development and Application of FRAX ® Copyright © 2013 Elsevier Inc. All rights reserved.
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Copyright © 2011 American Medical Association. All rights reserved. From: Association of BMD and FRAX Score With Risk of Fracture in Older Adults With Type 2 Diabetes JAMA. 2011;305(21):2184-2192. doi:10.1001/jama.2011.715 Figure Legend: BMD indicates bone mineral density; DM, diabetes mellitus. Ten-year cumulative risks were estimated using the Cox proportional hazards regression model baseline survival function, evaluated at 10 years, raised to the power of the relative hazard for each combination of DM group and T score at age 75 years. Rug plots indicate number of participants (aged 73-77 years) at each level of T score (for women with hip fracture, n = 41, 205, and 2604, for DM with insulin, DM without insulin, and no DM, respectively; for women with nonspine fracture, n = 41, 196, and 2468, respectively; and for men with both hip and nonspine fracture, n = 40, 306, and 1698, respectively). Error bars indicate 95% confidence intervals, correspond with femoral neck BMD T scores of −0.5, −1.5, −2.5, and −3.5 for women and −0.5, −1.5, and −2.5 for men, and are staggered for clarity. Date of download: 10/26/2017 Copyright © 2011 American Medical Association. All rights reserved.

Copyright © 2011 American Medical Association. All rights reserved. From: Association of BMD and FRAX Score With Risk of Fracture in Older Adults With Type 2 Diabetes JAMA. 2011;305(21):2184-2192. doi:10.1001/jama.2011.715 Figure Legend: FRAX indicates World Health Organization Fracture Risk Algorithm; DM, diabetes mellitus. Ten-year hip fracture risk based on FRAX score model vs risk estimated from hip fracture experience in the Study of Osteoporotic Fractures (women) and the 8-year hip fracture risk based on FRAX score model vs risk estimated from hip fracture experience in the Osteoporotic Fractures in Men Study. Rug plots indicate number of participants at each level of FRAX score (for women, n = 78, 442, and 7406, and for men, n = 80, 801, and 5113, for DM with insulin, DM without insulin, and no DM, respectively). Diagonal line is the line of equality where the FRAX predicted risk equals the estimated risk at 10 or 8 years. Error bars indicate 95% confidence intervals and are staggered for clarity. Date of download: 10/26/2017 Copyright © 2011 American Medical Association. All rights reserved.