Table 1 Characteristics of the 968 Women in the Study Group

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Presentation transcript:

Table 1 Characteristics of the 968 Women in the Study Group From: Diagnostic Accuracy of a Rapid Real-Time Polymerase Chain Reaction Assay for Universal Intrapartum Group B Streptococcus Screening Clin Infect Dis. 2009;49(3):417-423. doi:10.1086/600303 Clin Infect Dis | © 2009 by the Infectious Diseases Society of America

Table 2 Cross-Tabulation of Intrapartum Molecular Group B Streptococcus (GBS) Test Results by Intrapartum GBS Culture Results From: Diagnostic Accuracy of a Rapid Real-Time Polymerase Chain Reaction Assay for Universal Intrapartum Group B Streptococcus Screening Clin Infect Dis. 2009;49(3):417-423. doi:10.1086/600303 Clin Infect Dis | © 2009 by the Infectious Diseases Society of America

Table 3 Cross-Tabulation of the Antepartum and Intrapartum Group B Streptococcus (GBS) Culture Results From: Diagnostic Accuracy of a Rapid Real-Time Polymerase Chain Reaction Assay for Universal Intrapartum Group B Streptococcus Screening Clin Infect Dis. 2009;49(3):417-423. doi:10.1086/600303 Clin Infect Dis | © 2009 by the Infectious Diseases Society of America

Table 4 Cross-Tabulation of the Antepartum Group B Streptococcus (GBS) Culture Results and the Intrapartum Molecular GBS Test Results From: Diagnostic Accuracy of a Rapid Real-Time Polymerase Chain Reaction Assay for Universal Intrapartum Group B Streptococcus Screening Clin Infect Dis. 2009;49(3):417-423. doi:10.1086/600303 Clin Infect Dis | © 2009 by the Infectious Diseases Society of America

Figure 1 Flow diagram providing the results of the antenatal group B streptococcus (GBS) culture screening, the numbers of women who received intrapartum antibiotic prophylaxis (IAP), and outcomes for newborns. <sup>a</sup>Fourteen had GBS bacteriuria during pregnancy, and 7 had a previous infant with GBS disease. <sup>b</sup>Of 5 with obstetric risk factors, 3 received IAP. <sup>c</sup>One received IAP and had obstetric risk factors. <sup>d</sup>Of 15 with obstetric risk factors, 2 received IAP. <sup>e</sup>The mother had no obstetric risk factor and did not receive IAP. <sup>f</sup>Nine other newborns were colonized with GBS. <sup>g</sup>Two other newborns were colonized with GBS. “GBS infection” indicates probable early-onset GBS disease in newborns, which was defined by positive results of GBS culture of gastric fluid aspiration, deep ear swab specimens, or both and negative results of cultures of blood, cerebrospinal fluid, pulmonary, and/or urine specimens, in the presence of clinical signs and laboratory abnormalities consistent with infection. NA, not available. From: Diagnostic Accuracy of a Rapid Real-Time Polymerase Chain Reaction Assay for Universal Intrapartum Group B Streptococcus Screening Clin Infect Dis. 2009;49(3):417-423. doi:10.1086/600303 Clin Infect Dis | © 2009 by the Infectious Diseases Society of America

Figure 2 Projected outcomes of universal intrapartum screening and risk-based approach for women with unavailable results of molecular group B streptococcus (GBS) testing. Calculations were as follows. The overall GBS test yield equals 887/0;968=91.6%. The intrapartum GBS colonization prevalence equals 138/0;863=15.99%. The probability of infant infection given intrapartum maternal GBS colonization is 1.47% [30], and the relative risk of IAP for early-onset GBS is 0.20 [31], so the probability of infant infection given intrapartum maternal GBS colonization and intrapartum antibiotic prophylaxis (IAP) equals 1.47% ⋅ (1–0.200)=1.18%. The probability of infant infection given no intrapartum maternal GBS colonization is 0.0017% [30]. The probability of infant infection given maternal risk factors is 1.4% [30], and the relative risk of IAP for preterm premature rupture of membranes in early-onset GBS is 0.64 [31], so the probability of infant infection given maternal risk factors and IAP equals 1.4%⋅(1–0.640)=0.50%. The probability of infant infection given no maternal risk factors is 0.12% [30]. The estimated number of newborns equals 100,000⋅(988/968)=102,066 (taking into account twin deliveries), so the estimated GBS infection rate equals 192/102,066=0.188%. From: Diagnostic Accuracy of a Rapid Real-Time Polymerase Chain Reaction Assay for Universal Intrapartum Group B Streptococcus Screening Clin Infect Dis. 2009;49(3):417-423. doi:10.1086/600303 Clin Infect Dis | © 2009 by the Infectious Diseases Society of America