علم راهی بسوی آفریدگار جهان

Slides:



Advertisements
Similar presentations
MOLECULAR ENDOCRINOLOGY AND IMMUNOLOGY
Advertisements

Positive/Negative Feedback loop
Growth Hormone (GH) Holly Farris. What Is It? 191-amino acid, single chained polypeptide 191-amino acid, single chained polypeptide Synthesized, stored,
Adult Medical-Surgical Nursing
Chapter 32 Disorders of Endocrine Function
Chapter 32 Disorders of Endocrine Control of Growth and Metabolism
Pituitary and Hypothalamic Hormones Akrum Hamdy. Introduction Most pituitary and hypothalamic hormone are trophic hormones. This and other factors limit.
Pituitary Gland: Anterior Lobe By: Galindo, Fesas, Crandall, Aquiles, Houston 7A.
H ORMONES. W HAT IS A H ORMONE A hormone is a chemical substance released by a cell or a gland in one part of the body that sends out messages that affect.
Chapter 19 Care of Patients with Pituitary and Adrenal Gland Problems.
Endocrine Disorders.
Pituitary and hypothalamic diseases Dr.Malith Kumarasinghe MBBS( Colombo)
Copyright 2003 by Mosby, Inc. All rights reserved. CHAPTER 17 ENDOCRINE SYSTEM.
Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 60 Drugs for Disorders of the Adrenal Cortex.
1 Alterations of Hormonal Regulation Chapter 21. Mosby items and derived items © 2006 by Mosby, Inc. 2 Elevated or Depressed Hormone Levels  Failure.
The Endocrine System Chapter 18.
Copyright © 2006 by Elsevier, Inc. Endocrine Cells of the Hypothalamohypopyseal Axis & the Portal Circulation Median eminence Stalk Neurohypophysis Vein.
The Endocrine system Glands and hormones.
Hormones By: dr. hassan el-banna.
Bone Conditions Unit 3, Lesson 2.
Endo 1.07 The pituitary gland Anatomy and histology of the pituitary gland Growth hormone and its control Actions of growth hormone Excess and deficiency.
ENDOCRINE SYSTEM.
Anterior Pituitary Hormones. Physiological functions of growth hormone Growth hormone promotes growth of many body tissues. GH,also called somatotropic.
Endocrine System Biology Introduction (1) What are hormones? (2) What are the functions of hormones? (3) What are the types of hormones? – Amino.
Small protein expressed from anterior lobe of pituitary produced by Somatotroph cells of the anterior pituitary Growth hormone (hGH) is a peptide hormone.
Growth Hormone Jessica crownover. GROWTH HORMONE IS… is a peptide hormone that stimulates growth, cell reproduction and regeneration in humans and other.
The Pituitary Gland Posterior pituitary The hypothalamus significantly influences the pituitary gland The hypothalamus makes and releases the hormones.
Chapter 10 Endocrine System
Causes 1. Infarction : Sheehan’s syndrome 2. Iatrogenic : Radiation, urgery 3. Invasive : Large pituitary tumors CRANIOPHARYNGIOMA 4. Infiltration : Sarcoidosis,
Growth Hormone Victoria Brown.
Chapter 32 Disorders of Endocrine Function
Week 2 Endocrine Anatomy and Physiology review & Pituitary Disturbances Ann MacLeod, MPH, BScN, RN.
ANT. PITUITARY : ( UNDER INFLUENCE OF HYPTHALAMUS  RELEASING HORMONES ALL RELEASING HORMONES ARE STIMULATORY EXCEPT DOPMAMINE  INHIBITS PROLACTIN SOMATOSTAIN.
Endocrine System. Endocrine glands are composed of cells that secrete: – Hormones amino acid derivatives peptides and proteins steroids.
Pituitary Hormones. Turkish saddle Intermediate Lobe.
Endocrine System PA 544: Clinical Anatomy Tony Serino, Ph.D. Biology Department Misericordia Univ.
Dr. Eman El Eter The pituitary Gland: Anterior pituitary hormones. Posterior pituitary hormones.
Endocrinology Dr. Hana Alzamil.
HYPOTHALAMUS Nicolette Cefai and Malia Bybee. Location  In the brain below the thalamus and above the pituitary gland.
Hypothalamic & Pituitary Hormones
Growth Hormone (somatotrophin)
GROWTH HORMONE Dr. Hany Ahmed
By: Chris Baker, Iyoma Edache, Victoria Sendanyoye
1 ENDOCRINE SYSTEM. 2Hormones Self-regulating system Production –Extremely small amounts –Highly potent Affect: –Growth –Metabolism –Behavior Two categories:
Regents Biology Animals rely on two systems for regulation: Nervous System is a system of nerve cells called neurons. It consists of a central.
For each hormone you should know the following: Chemical Structure Source and mode of action Metabolic effects Clinical disorders Laboratory use.
Hypo and Hypersecretion
FUNCTIONS & CONTROL OF ANTERIOR PITUITARY,GROWTH HORMONE. DR.HAROON RASHID.
Videos Stress response Adrenaline. Chapter 15 Section 15.3 Hormones that Affect Metabolism.
Copyright © 2016, 2013, 2010 by Saunders, an imprint of Elsevier Inc. All rights reserved. Chapter 59 Drugs Related to Hypothalamic and Pituitary Function.
Copyright © 2016, 2013, 2010 by Saunders, an imprint of Elsevier Inc. All rights reserved. Chapter 60 Drugs for Disorders of the Adrenal Cortex.
Growth hormone.
Abnormalities of Growth (GH) Lecture NO: 2nd MBBS
Endocrine System Disorders
Pituitary Gland..
You will be given the answer. You must give the correct question.
Growth Hormone Prof. K. Sivapalan.
Endocrine System Chapter 10.
AL-Mustansiriyah University College of science Biology Dept
Pituitary Hormones.
Clinical Anatomy Tony Serino, Ph.D.
The Endocrine System.
Hormones The Endocrine System.
Abnormalities of Growth (GH) Lecture NO: 2nd MBBS
Hormones of the Pituitary Gland
2I&list=PLsUTfStTI4Yc0KCFH6mG7- SGmDfEP4nGd Homeostasis
GROWTH HORMONE Victoria Brown. Structure of hormone  191 amino acids long  Protein structure  4 helices that help it bind its receptor  2 strong sulfide.
Interventions for Clients with Pituitary and Adrenal Gland Problems
chapter 16-2: regulation of the Endocrine system
Presentation transcript:

علم راهی بسوی آفریدگار جهان Growth Hormone (GH; Somatotropin) Dr. Radmanesh

Human Growth Hormone Polypeptide 191 amino acid residues MW = 22125 daltons Highly hydrophobic proteins

Regulation of GH Expression in Somatotrophs GHRH somatostatin AC Gs Gi (-) cAMP PKA PIT-1 GH synthesis A txn factor in the Pit

Actions of Growth Hormone: increases skeletal growth increases muscular growth increases amino acid uptake and protein synthesis increased use of lipids for energy decreased storage of carbohydrates 3

Feedback control of growth hormone

ganong Ganong

Ganong

Downloaded from: StudentConsult (on 15 June 2006 06:30 AM) © 2005 Elsevier

Downloaded from: StudentConsult (on 15 June 2006 06:30 AM) © 2005 Elsevier

Downloaded from: StudentConsult (on 15 June 2006 06:30 AM) © 2005 Elsevier

Ganong

Amount of Growth Hormone

CLINICAL PICTURE OF HYPOPITUITARISM DEPENDS ON HORMONES LOST 1. Lack of FSH LH :  1. Hypogonadim 2. Lack of TSH:  hypothyroidism 3. Lack of ACTH:  adrenocortical insufficiency 4. Prolactin deficiency 5. If all of the above: PANHYPOPITUITARISM 6. In children: GH: short stature

Cause of Hypopituitarism Shock or severe hypotension Head trauma Brain tumors or infection Genetic considerations

What Causes this Disorder? Hyposecretion (underproduction) of the Growth Hormone during growing years causes slow bone growth and the epiphyseal plates close before normal height is reached. This condition is known as Dwarfism.

Laron dwarfs, who lack normal GH receptors but have normal GH secretion.

Care Replacement of deficient hormones Androgen therapy Estrogens and progesterone Growth hormone

Hyperpituitarism Hormone oversecretion occurs with pituitary tumors or hyperplasia Genetic considerations Pituitary adenoma

Gigantism Gigantism is the onset of growth hormone hypersecretion before puberty.

Acromegaly

Downloaded from: StudentConsult (on 15 June 2006 06:30 AM) © 2005 Elsevier

Complications of Acromegaly Cardiovascular Ischemic heart disease Cardiomyopathy Congestive heart failure Arrhythmias Hypertension Respiratory Kyphosis Metabolic Diabetes mellitus/IGT Hyperlipidemia http://www.endotext.com/neuroendo/neuroendo5e/neuroendoframe5e.htm

Patient-Centered Collaborative Care Assessment Nonsurgical management: Drug therapy- to reduce GH secretion or the effects on tissues Somatostatin analogues Dopamine agonists Growth hormone antagonist Radiation Gamma knife procedure Usually one time treatment

Surgical Management

Pituitary Surgery