Copyright © 2012 American Medical Association. All rights reserved. From: Effect of Silymarin (Milk Thistle) on Liver Disease in Patients With Chronic Hepatitis C Unsuccessfully Treated With Interferon TherapyA Randomized Controlled Trial JAMA. 2012;308(3):274-282. doi:10.1001/jama.2012.8265 Figure Legend: ALT indicates alanine aminotransferase; HCV, hepatitis C virus.aPatients could have more than 1 reason for ineligibility. Date of download: 10/23/2017 Copyright © 2012 American Medical Association. All rights reserved.

Copyright © 2012 American Medical Association. All rights reserved. From: Effect of Silymarin (Milk Thistle) on Liver Disease in Patients With Chronic Hepatitis C Unsuccessfully Treated With Interferon TherapyA Randomized Controlled Trial JAMA. 2012;308(3):274-282. doi:10.1001/jama.2012.8265 Figure Legend: Means estimated by fitting a linear mixed model with alanine aminotransferase (ALT) as outcome and treatment group and time point (treated as categorical) and their interaction as covariates. Dotted line at y = 45 U/L indicates the ALT value considered the upper limit of normal for this study. Time axis has been shifted slightly to the right by 0.3 units for 420-mg silymarin and 0.6 units for 700-mg silymarin to separate the error bars. Error bars indicate 95% CIs. Date of download: 10/23/2017 Copyright © 2012 American Medical Association. All rights reserved.