PGAM5 is important for A. mediating apoptosis

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Presentation transcript:

PGAM5 is important for A. mediating apoptosis B. mediating multiple necrotic pathways C. mitochondria fragmentation D. formation of the RIP1/RIP3 complex in response to TNF treatment. E. None of above

RIP3 is important for A. mediating apoptosis B. mediating multiple necrotic pathways C. mitochondria fragmentation D. TNF-induced necrosis. E. None of above

MLKL is important for A. mediating apoptosis B. mediating multiple necrotic pathways C. phosphorylation of DRP1 D. TNF-induced necrosis. E. None of above

PGAM5 is a protein on the plasma membrane a protein in the cytoplasm a protein on mitochondria a protein that translocates to mitochondria during necrosis. None of above.

DRP1 is a protein on the plasma membrane a protein in the cytoplasm a protein on mitochondria a protein that translocates to mitochondria during necrosis. None of above.

DRP1 needs to do the following to promote necrosis be activated by PGAM5 be dephosphorylated translocate to mitochondria. have GTPase activity All of above.