Fig. 1. Serum activity of the osteoclast-specific enzyme TRAP-5b and serum levels of RANKL and OPG, key regulators involved in osteoclast differentiation.

Slides:

Advertisements

Similar presentations

Inflammation Due To RA.

Advertisements

Fig. 1. Flow diagram of study participants and outcomes.

From: An open day in the metric space

FIG. 1. Scanning electronic microscope image of the unmodified beads; all the bead samples were identical in appearance and size to the unmodified shown.

Fig. 3. Plot of overall survival by adjuvant therapy for patient subgroups. (A) Patients with M0 disease (n = 411). (B) Patients receiving 36 Gy craniospinal.

High molecular weight hyaluronic acid regulates osteoclast formation by inhibiting receptor activator of NF-κB ligand through Rho kinase W. Ariyoshi,

Figure 1 The spatial and temporal distribution of diarrhoea rates

Immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple myeloma- induced osteoclast formation and the RANKL/OPG ratio in the myeloma microenvironment.

Figure 1. CD11b+CD33+CD14+HLA-DR−/lo myeloid-derived suppressor cell expansion by human immunodeficiency virus.

FIGURE 4: Mean change from baseline in iPTH concentration during treatment and 60 days after treatment withdrawal. Data are shown as the mean change ±

Figure 5. Targeted inhibition of DNMT enzymes reduces the fibrotic markers collagen and ASMA. The impact of reducing DNMT levels on the expression of fibrosis-related.

Fig. 1 ( A ) COX-2 mRNA abundance in hVSMC incubated without (−) and with (+) fetal calf serum (FCS, 2 h) and vehicle (control), cyclosporine A (CsA 100.

Fig. 3. Quantitative analysis of calcification at the aortic root showing the effect of long-term PD administration of PPi in mice . ( A ) Calcification.

Neuropeptide Y accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells Xiao-chuan Gu, Xiao-Bin Zhang, Bing Hu, Ying.

From: Political Leadership and Power Redistribution

Fig. 1 GBM TIMs expand to inhibit vaccine-induced T-cell mediated tumor cytolysis via PD-1/PD-L1 regulatory pathway. (A, D) CD163, DAPI, (B, E) PD-L1,

Figure 1. Validation of BCP rat models (A) Radiological images of the MRMT-1-injected and Hank’s buffer-injected left hindpaw of the rats, 21 days after.

Figure 1. BM-MSCs from SLE patients showed senescence characteristics (A,B) SA-β-gal was used to examine BM-MSC senescence. The number of SA-β-gal-positive.

FIGURE 1 Bivariate relationship between serum urea levels and serum Hcit levels, according to different nutritional regimens, namely FD, MD and VLPD. From:

Fig. 1 Changes in biochemical assessment of CKD-MBD over time: Cy/+ rats were treated with diet only (CKD CTL), R-568, R Ca or calcium alone (Ca).

Fig. 2. Effects of UVB on COX-2 and cytokine mRNA expression

Figure 1. Herbacetin binds to AKT1/2 and suppresses each respective kinase activity. The effect of herbacetin on (A) PI3K/AKT and (B) MAPK signaling pathway.

Fig. 6. Knockdown of TCF-4 inhibits TCTP-induced glioma cell proliferation in vitro and in vivo. (A) TCF-4 was knocked down in U-251/TCTP and H-4/TCTP.

Fig. 4 Glucose concentration in the first 3 h of the dialysis session (blue circles) or equivalent time of the following day without dialysis (red circles).

Figure 1. Phenotype of CD8+ T cells and CD4+ T cells in human immunodeficiency virus (HIV)–seropositive women who are seropositive.

Fig 1 Perfusion index values at different time intervals in patients with successful and failed blocks. A reference line at PI 3.3 is provided. Horizontal.

Figure 1. Overall survival of patients receiving alternative medicine (solid lines) vs conventional cancer treatment (dashed lines). Overall survival of.

FIGURE 1: The flow chart of the systematic review: paper retrieval and selection. From: Pregnancy in dialysis patients in the new millennium: a systematic.

Fig. 1 Selection of patients

Fig. 1 Flow diagram of patient selection and study design.

Figure 1 Flow of data processing

Figure 1. Phenotypic and functional characterization of nasopharyngeal carcinoma (NPC)– and healthy donor (HD)–derived exosomes. A) Electron microscopy.

Figure 1. Percentage of trainees is represented on the y-axis for each competency/knowledge item represented in the x-axis. Only Poor/Fair (P/F) ratings.

Fig. 4. Effect of FTY720 on brain tumor stem cell (BTSC) invasiveness

FIGURE 1 Trial profile. The safety population was defined as all randomly assigned patients who received at least one dose of study drug. All patients.

Peyman Hadji, Robert Coleman, Michael Gnant

Figure 1. Impact ratings for prospective memory lapses for younger (~age 30), middle-age (~age 50), and older (~age 65) adults. From: Daily Memory Lapses.

Fig. 4. TR3-dependent induction of ATF3 by DIM-C-pPhOCH 3 in human pancreatic cancer cells. ( A ) Induction of ATF3 by DIM-C-pPhOCH 3

Figure 6. RRs for clinical cure rates stratified by different diseases

FIGURE 1: Urinary proteome analysis in nephrology

Fig. 1. Intrarenal resistance index (RI) by stage of CKD (classification followed the K/DOQI guidelines [ 2 ]). Each box shows the median, quartiles and.

Figure 2. Macrophages in dystrophic muscle in vivo and in vitro express Klotho. (A) A cross-section of 4-week-old mdx muscle labeled with antibodies to.

Figure 1. Herbacetin binds to AKT1/2 and suppresses each respective kinase activity. The effect of herbacetin on (A) PI3K/AKT and (B) MAPK signaling pathway.

High molecular weight hyaluronic acid regulates osteoclast formation by inhibiting receptor activator of NF-κB ligand through Rho kinase W. Ariyoshi,

by Benjamin J. Frisch, John M. Ashton, Lianping Xing, Michael W

Induction of osteoclast-like cells derived from the synovial lavage fluids of patients with temporomandibular joint disorders H. Takano, D.D.S., W. Ariyoshi,

Figure 1. Artemisinin derivatives inhibited EOC growth and arrested the cell cycle at the G2/M phase (A) SKOV3 and primary epithelial ovarian cancer (EOC)

Dual Role of Act1 in Keratinocyte Differentiation and Host Defense: TRAF3IP2 Silencing Alters Keratinocyte Differentiation and Inhibits IL-17 Responses

Bone Marrow-Derived Mesenchymal Stem Cells Expressing Thioredoxin 1 Attenuate Bleomycin-Induced Skin Fibrosis and Oxidative Stress in Scleroderma Miao.

Volume 6, Issue 4, Pages (April 2016)

Volume 23, Issue 3, Pages (March 2013)

Interferon-γ enhances the efficacy of autogenous bone grafts by inhibiting postoperative bone resorption in rat calvarial defects Peiqi Li, DDS, Yoshitomo.

Christine V. Ichim, Džana D

Volume 14, Issue 7, Pages (July 2007)

Poly(I:C)-Treated Human Langerhans Cells Promote the Differentiation of CD4+ T Cells Producing IFN-γ and IL-10 Laetitia Furio, Hermine Billard, Jenny.

Kenichi Miharada, Valgardur Sigurdsson, Stefan Karlsson Cell Reports

Under osteoporotic conditions, several proinflammatory cytokines ...

Leslie van der Fits, Jacoba J. Out-Luiting, Cornelis P

Volume 13, Issue 6, Pages (November 2015)

P38 Mitogen-Activated Protein Kinase Mediates Dual Role of Ultraviolet B Radiation in Induction of Maturation and Apoptosis of Monocyte-Derived Dendritic.

Volume 7, Issue 1, Pages (April 2014)

Figure 1. RSPO3 expression is upregulated in bladder cancer

PPARδ Is a Type 1 IFN Target Gene and Inhibits Apoptosis in T Cells

Fig. 2 Case 2. Levels of serum creatinine and anti-GBM antibodies before and during treatment with cyclophosphamide, ... Fig. 2 Case 2. Levels of serum.

Intrathymic T Cell Development and Selection Proceeds Normally in the Absence of Glucocorticoid Receptor Signaling Jared F Purton, Richard L Boyd, Timothy.

Negative Selection at the Pre-BCR Checkpoint Elicited by Human μ Heavy Chains with Unusual CDR3 Regions Yoshiyuki Minegishi, Mary Ellen Conley Immunity

Figure 1 Collagen is associated with ChemR23 expression in human and murine vascular smooth muscle cells. (A) Positive ... Figure 1 Collagen is associated.

Figure 1 Vitamin D high excess supplementation raises serum 25-OH-vitamin D3 as well as serum and urine calcium ... Figure 1 Vitamin D high excess supplementation.

Rapamycin inhibits IL-4—induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo by Holger Hackstein, Timucin Taner,

IAP antagonists enhance osteoclastogenesis in vitro.

Presentation transcript:

Fig. 1. Serum activity of the osteoclast-specific enzyme TRAP-5b and serum levels of RANKL and OPG, key regulators involved in osteoclast differentiation in 42 stable renal transplant patients. Values are given as median, 25–75th percentile (bars) and minimum/maximum (whiskers), *P < 0.05. From: Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis—implications for post-transplantation bone disease Nephrol Dial Transplant. 2011;26(12):4115-4123. doi:10.1093/ndt/gfr214 Nephrol Dial Transplant | © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Fig. 2. Multinucleated osteoclast precursor cells and their TRAP expression after 10 days of culture in the presence of M-CSF and RANKL. Values are given as mean ± SD, *P < 0.05 versus control. From: Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis—implications for post-transplantation bone disease Nephrol Dial Transplant. 2011;26(12):4115-4123. doi:10.1093/ndt/gfr214 Nephrol Dial Transplant | © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Fig. 3. Osteoclast activity was detected after prolonged culture for 28 days in the presence of RANKL and M-CSF on hydroxyapatite-coated wells. After von Kossa staining, the area of resorbed mineral was quantified by its bright appearance in the transmitted light. Values are given as mean ± SD, *P < 0.05 versus control. From: Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis—implications for post-transplantation bone disease Nephrol Dial Transplant. 2011;26(12):4115-4123. doi:10.1093/ndt/gfr214 Nephrol Dial Transplant | © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Fig. 4. Real-time PCR analysis in osteoclast precursors following 8 days of culture in the presence of recombinant M-CSF/RANKL. Target gene expression was normalized for 1 million copies ribosomal RNA (18S). Results are given as mean ± SD and represent five independent experiments of different donors. The mean value of the control groups was assigned to 1, *P < 0.05 versus control. From: Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis—implications for post-transplantation bone disease Nephrol Dial Transplant. 2011;26(12):4115-4123. doi:10.1093/ndt/gfr214 Nephrol Dial Transplant | © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Fig. 5. Real-time PCR analysis in MSC Fig. 5. Real-time PCR analysis in MSC. Target gene expression was normalized for 1 million copies ribosomal RNA (18S). Each column represents the mean of independent culture experiments of a total of four different donors. The mean value of the control groups was assigned to 1. From: Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis—implications for post-transplantation bone disease Nephrol Dial Transplant. 2011;26(12):4115-4123. doi:10.1093/ndt/gfr214 Nephrol Dial Transplant | © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Fig. 6. Effect of SRL on the viability of mononuclear cells/osteoclast precursors at different time points after isolation as detected by Annexin V-FITC and propidium iodide staining with additional CD14 PE labelling and subsequent FACS analysis. As depicted in the upper panel, addition of SRL led to some induction of apoptosis. However, apoptosis promoting actions of SRL could largely be prevented by M-CSF and RANKL co-administration. Omitting M-CSF and RANKL from the culture medium was more pro-apoptotic than the effect of SRL treatment. SRL, M-CSF and RANKL primarily influenced mononuclear cell survival as depicted by the fraction of CD14-positive cells in the various treatment groups and time points. From: Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis—implications for post-transplantation bone disease Nephrol Dial Transplant. 2011;26(12):4115-4123. doi:10.1093/ndt/gfr214 Nephrol Dial Transplant | © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Fig. 7. ( A ) Overview of osteoclastogenesis from haematopoietic precursor cells into mature osteoclasts. RANKL and RANK are essential for osteoclast maturation and activation. OPG can bind and antagonize RANKL, thereby inhibiting osteoclastogenesis (schema adapted from W.J. Boyle [ 1 ]). ( B ) Gives an overview about the key in vitro and in vivo findings how SRL, CI and MMF may affect osteoclast maturation at different stages. From: Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis—implications for post-transplantation bone disease Nephrol Dial Transplant. 2011;26(12):4115-4123. doi:10.1093/ndt/gfr214 Nephrol Dial Transplant | © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com