Volume 14, Issue 10, Pages (September 2013)

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Volume 14, Issue 10, Pages 1009-1019 (September 2013) Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies The Lancet Oncology Volume 14, Issue 10, Pages 1009-1019 (September 2013) DOI: 10.1016/S1470-2045(13)70301-2 Copyright © 2013 Endogenous Hormones and Breast Cancer Collaborative Group. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Geometric mean oestradiol concentrations (A) and progesterone concentrations (B), by phase of menstrual cycle Adjusted for study and age at blood collection. Vertical lines show 95% CIs. The Lancet Oncology 2013 14, 1009-1019DOI: (10.1016/S1470-2045(13)70301-2) Copyright © 2013 Endogenous Hormones and Breast Cancer Collaborative Group. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Odds ratios for breast cancer associated with sex hormones and SHBG Black squares show odds ratios in quintiles (Q1–Q5; study-specific fifths after adjustment for phase of cycle within each study), and the horizontal lines show 95% CIs. The area of each square is proportional to the amount of statistical information (inverse of the variance of the logarithm of the odds ratios). The diamonds show the odds ratio for a doubling in concentration, and the widths of the diamonds show the 95% CIs. Estimates are from conditional logistic regression on case–control sets matched within each study. DHEAS=dehydroepiandrosterone sulphate. SHBG=sex hormone-binding globulin. The Lancet Oncology 2013 14, 1009-1019DOI: (10.1016/S1470-2045(13)70301-2) Copyright © 2013 Endogenous Hormones and Breast Cancer Collaborative Group. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Geometric mean hormone and SHBG concentrations (with 95% CIs) in controls, by body-mass index Adjusted for study, age at blood collection, and phase of menstrual cycle. *Means scaled to overall mean concentration (vertical line). † Significant (p<0·05) interaction with study. DHEAS=dehydroepiandrosterone sulphate. SHBG=sex hormone-binding globulin. The Lancet Oncology 2013 14, 1009-1019DOI: (10.1016/S1470-2045(13)70301-2) Copyright © 2013 Endogenous Hormones and Breast Cancer Collaborative Group. Open Access article distributed under the terms of CC BY Terms and Conditions