Effect of 11,12-epoxyeicosatrienoic acid as an additive to st

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Presentation transcript:

Effect of 11,12-epoxyeicosatrienoic acid as an additive to st Effect of 11,12-epoxyeicosatrienoic acid as an additive to st. thomas’ cardioplegia and university of wisconsin solutions on endothelium-derived hyperpolarizing factor– mediated function in coronary microarteries: influence of temperature and time Qin Yang, MD, PhD, Rong-Zhen Zhang, MD, Anthony P.C Yim, MD, Guo-Wei He, MD, PhD, DSc The Annals of Thoracic Surgery Volume 76, Issue 5, Pages 1623-1630 (November 2003) DOI: 10.1016/S0003-4975(03)00735-5

Fig 1 Concentration-relaxation curves for bradykinin in the U46619 (1 nmol/L) plus endothelin-1 (6 nmol/L)–precontracted microarteries (see Methods) with the presence of indomethacin (7 μmol/L), NG-nitro-L-arginine (300 μmol/L), and oxyhemoglobin (20 μmol/L) after exposure to (A) Krebs solution (control; solid circles) or University of Wisconsin (UW) solution (open circles) or (B) UW solution without (solid circles) or with (open circles) 11,12-epoxyeicosatrienoic acid at 4°C for 4 hours. Data are shown as mean ± SEM. *p less than 0.05, **p = 0.01 compared with the control (n = 8). Unpaired t test in (A) and paired t test in (B). The Annals of Thoracic Surgery 2003 76, 1623-1630DOI: (10.1016/S0003-4975(03)00735-5)

Fig 2 Concentration-relaxation curves for bradykinin in the U46619 (10 nmol/L)–precontracted microarteries (see Methods) with the presence of indomethacin (7 μmol/L), NG-nitro-L-arginine (300 μmol/L), and oxyhemoglobin (20 μmol/L) after exposure to (A) Krebs solution (control; solid circles) or St. Thomas’ Hospital (ST) solution (open circles) or (B) ST solution without (solid circles) or with (open circles) 11,12-epoxyeicosatrienoic acid at 22°C for 1 hour. Data are shown as mean ± SEM. *p less than 0.05 compared with the control in (A); **p less than 0.01 compared with ST in (B) (n = 8, paired t test). The Annals of Thoracic Surgery 2003 76, 1623-1630DOI: (10.1016/S0003-4975(03)00735-5)

Fig 3 Concentration-relaxation curves for bradykinin in the U46619 (10 nmol/L)–precontracted microarteries (see Methods) with the presence of indomethacin (7 μmol/L), NG-nitro-L-arginine (300 μmol/L), and oxyhemoglobin (20 μmol/L) after exposure to (A) Krebs solution (control; solid circles) or St. Thomas’ Hospital (ST) solution (open circles) or (B) ST solution without (solid circles) or with (open circles) 11,12-epoxyeicosatrienoic acid at 4°C for 1 hour. Data are shown as mean ± SEM (n = 7, paired t test). The Annals of Thoracic Surgery 2003 76, 1623-1630DOI: (10.1016/S0003-4975(03)00735-5)

Fig 4 Concentration-relaxation curves for bradykinin in the U46619 (1 nmol/L) plus endothelin-1 (6 nmol/L)–precontracted microarteries (see Methods) with the presence of indomethacin (7 μmol/L), NG-nitro-L-arginine (300 μmol/L), and oxyhemoglobin (20 μmol/L) after exposure to (A) Krebs solution (control; solid circles) or St. Thomas’ Hospital (ST) solution (open circles) or (B) ST solution without (solid circles) or with (open circles) 11,12-epoxyeicosatrienoic acid at 4°C for 4 hours. Data are shown as mean ± SEM (n = 8, paired t test). The Annals of Thoracic Surgery 2003 76, 1623-1630DOI: (10.1016/S0003-4975(03)00735-5)