Two Faces of Progressive Dyspnea

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Two Faces of Progressive Dyspnea Steven M. Kawut, MD, Michael Mandel, MD, FCCP, Selim M. Arcasoy, MD CHEST Volume 117, Issue 5, Pages 1500-1504 (May 2000) DOI: 10.1378/chest.117.5.1500 Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 1 Top, chest radiograph revealing no abnormalities. Bottom, high-resolution CT scan showing bilateral patchy areas of ground-glass attenuation. CHEST 2000 117, 1500-1504DOI: (10.1378/chest.117.5.1500) Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 2 Chest radiographs (A, B) and CT scans (C, D) showing bilateral interstitial infiltrates anteriorly in lower lobes with significant progression over 1 year (B, D). CHEST 2000 117, 1500-1504DOI: (10.1378/chest.117.5.1500) Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 3 Top, histology of a lung biopsy specimen from Case 1 reveals multinucleated giant cells and noncaseating granulomata. Bottom, histological findings of Case 2 include mononuclear interstitial inflammation and fibrosis, scattered noncaseating granulomata, and foci of intra-alveolar fibrinous exudate. Courtesy of Leslie Litzky, MD, University of Pennsylvania. CHEST 2000 117, 1500-1504DOI: (10.1378/chest.117.5.1500) Copyright © 2000 The American College of Chest Physicians Terms and Conditions