Evaluation of a novel anti-ischemic agent in acute coronary syndromes: Design and rationale for the Metabolic Efficiency with Ranolazine for Less Ischemia.

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Date of download: 5/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: The thrombolysis in myocardial infarction risk score.

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Presentation transcript:

Evaluation of a novel anti-ischemic agent in acute coronary syndromes: Design and rationale for the Metabolic Efficiency with Ranolazine for Less Ischemia in Non–ST- elevation acute coronary syndromes (MERLIN)-TIMI 36 trial David A. Morrow, MD, MPH, Benjamin M. Scirica, MD, Ewa Karwatowska-Prokopczuk, MD, PhD, Allan Skene, PhD, Carolyn H. McCabe, BS, Eugene Braunwald, MD American Heart Journal Volume 152, Issue 2, Pages 400.e1-400.e9 (August 2006) DOI: 10.1016/j.ahj.2006.06.016 Copyright © 2006 Mosby, Inc. Terms and Conditions

Figure 1 Adverse consequences of Na and Ca overload in ischemia and heart failure. CHF, Congestive heart failure; Abnl, abnormal. Data from Eur Heart J 1994;9 (Supp I):13-17.11 American Heart Journal 2006 152, 400.e1-400.e9DOI: (10.1016/j.ahj.2006.06.016) Copyright © 2006 Mosby, Inc. Terms and Conditions

Figure 2 Study schema for MERLIN-TIMI 36. UA, Unstable angina; NSTEMI, non–ST-segment elevation MI; sx, symptoms. American Heart Journal 2006 152, 400.e1-400.e9DOI: (10.1016/j.ahj.2006.06.016) Copyright © 2006 Mosby, Inc. Terms and Conditions