Volume 376, Issue 9747, Pages (October 2010)

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Presentation transcript:

Volume 376, Issue 9747, Pages 1155-1163 (October 2010) Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): a randomised trial Prof Gordon JS Rustin, MD, Maria EL van der Burg, MD, Clare L Griffin, MSc, David Guthrie, FRCR, Alan Lamont, FRCR, Prof Gordon C Jayson, FRCP, Gunnar Kristensen, MD, César Mediola, MD, Corneel Coens, MSc, Wendi Qian, PhD, Prof Mahesh KB Parmar, DPhil, Dr Ann Marie Swart, MD The Lancet Volume 376, Issue 9747, Pages 1155-1163 (October 2010) DOI: 10.1016/S0140-6736(10)61268-8 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile ULN=upper limit of normal. The Lancet 2010 376, 1155-1163DOI: (10.1016/S0140-6736(10)61268-8) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 2 Main outcome measures Kaplan-Meier plots for (A) overall survival, (B) second-line chemotherapy, (C) third-line treatment or death, and (D) first deterioration in Global Health Score or death. (E) Duration of time spent with good Global Health Score during the first 2 years from randomisation. HR=hazard ratio. The Lancet 2010 376, 1155-1163DOI: (10.1016/S0140-6736(10)61268-8) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 3 Treatment interactions Data are number of events/number of patients, observed (O) minus expected (E) events, variance, and hazard ratio (HR; 95% CI). The Lancet 2010 376, 1155-1163DOI: (10.1016/S0140-6736(10)61268-8) Copyright © 2010 Elsevier Ltd Terms and Conditions