Large-scale independent validation of the nuclear factor-kappa B p65 prognostic biomarker in prostate cancer Philippe O. Gannon, Laurent Lessard, Louis-Mathieu.

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Large-scale independent validation of the nuclear factor-kappa B p65 prognostic biomarker in prostate cancer Philippe O. Gannon, Laurent Lessard, Louis-Mathieu Stevens, Valérie Forest, Louis R. Bégin, Sarah Minner, Pierre Tennstedt, Thorsten Schlomm, Anne-Marie Mes-Masson, Fred Saad European Journal of Cancer Volume 49, Issue 10, Pages 2441-2448 (July 2013) DOI: 10.1016/j.ejca.2013.02.026 Copyright © 2013 Elsevier Ltd Terms and Conditions

Fig. 1 Illustration of BCR and survival. (A) Freedom from biochemical recurrence (BCR) and (B) long-term survival of patients after radical prostatectomy of a documented malignant tumour. The embedded table reports point estimates and number at risk at 180months. European Journal of Cancer 2013 49, 2441-2448DOI: (10.1016/j.ejca.2013.02.026) Copyright © 2013 Elsevier Ltd Terms and Conditions

Fig. 2 Immunohistochemistry of nuclear factor-kappa B (NF-κB) p65. Examples of NF-κB immunostaining in prostate tissue. (A) Weak cytoplasmic staining and no nuclear staining. (B) Inset of A. (C) Strong cytoplasmic staining and no nuclear staining. (D) Inset of C. (E) Strong cytoplasmic staining and positive nuclear staining. (F) Inset of E. (G) Frequency of NF-κB cytoplasmic expression according to staining intensities and nuclear frequency according to nuclear percentage. European Journal of Cancer 2013 49, 2441-2448DOI: (10.1016/j.ejca.2013.02.026) Copyright © 2013 Elsevier Ltd Terms and Conditions

Fig. 3 Nuclear factor-kappa B (NF-κB) expression and biochemical recurrence (BCR). Kaplan–Meier curves illustrating the relationship between NF-κB expression and BCR. (A) Nuclear NF-κB frequency: 0% (black curve), 1% (blue curve), 1–5% (green curve), >5% (red curve). Log rank=30.748, P-value <0.001. (B) Cytoplasmic NF-κB intensity: 0 (black curve), 1 (blue curve), 2 (green curve), 3 (red curve). Log rank=2.331, P-value=0.507. (C) Dichotomised NF-κB variable: nuclear (<1%)/cytoplasm (3) (black curve), nuclear (≥1%)/cytoplasm (3) (blue curve), nuclear (<1%)/cytoplasm (<3) (green curve), nuclear (≥1%)/cytoplasm (<3) (red curve). Log rank=22.506, P-value<0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this book.) European Journal of Cancer 2013 49, 2441-2448DOI: (10.1016/j.ejca.2013.02.026) Copyright © 2013 Elsevier Ltd Terms and Conditions