Efficacy and Safety of Oral Chelators in Treatment of Patients With Wilson Disease Karl Heinz Weiss, Florentine Thurik, Daniel Nils Gotthardt, Mark Schäfer,

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Presentation transcript:

Efficacy and Safety of Oral Chelators in Treatment of Patients With Wilson Disease Karl Heinz Weiss, Florentine Thurik, Daniel Nils Gotthardt, Mark Schäfer, Ulrike Teufel, Franziska Wiegand, Uta Merle, Daniela Ferenci– Foerster, Andreas Maieron, Rudolf Stauber, Heinz Zoller, Hartmut H. Schmidt, Ulrike Reuner, Harald Hefter, Jean Marc Trocello, Roderick H.J. Houwen, Peter Ferenci, Wolfgang Stremmel Clinical Gastroenterology and Hepatology Volume 11, Issue 8, Pages 1028-1035.e2 (August 2013) DOI: 10.1016/j.cgh.2013.03.012 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 Number of treatments in the study cohort. Hepatic and neurologic outcomes were scored for each treatment at defined time points (6, 12, 24, 36, and 48 mo) as follows: improved to normal, improved but not normal, unchanged, worsened, or asymptomatic over duration. Combination therapies (25 treatments with DPA and zinc; 21 treatments with trientine and zinc) were not included in the numbers provided in this flow chart and were not included in the statistical analysis. Clinical Gastroenterology and Hepatology 2013 11, 1028-1035.e2DOI: (10.1016/j.cgh.2013.03.012) Copyright © 2013 AGA Institute Terms and Conditions

Figure 2 Discontinuation of treatments for (A) any cause or because of (B) adverse events, analyzed by Kaplan–Meier estimation. Clinical Gastroenterology and Hepatology 2013 11, 1028-1035.e2DOI: (10.1016/j.cgh.2013.03.012) Copyright © 2013 AGA Institute Terms and Conditions