The Effects of Arterial Blood Pressure Reduction on Endocan and Soluble Endothelial Cell Adhesion Molecules (CAMs) and CAMs Ligands Expression in Hypertensive.

Slides:

Advertisements

Similar presentations

Supplementary Materials. Supplementary Figure S1. The effect of the freezing/thawing procedure on CD15 and CD33 marker staining on human PBMCs. Prostate.

Advertisements

Chapter 13 Leukocyte Activation and Migration Dr. Capers

Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: Homocysteine Modulates the CD40/CD40L System J Am.

Sae-Kyung Lee, Suh Yee Goh, Yuan Qi Wong, Jeak Ling Ding EBioMedicine

Echocardiographic Changes in Patients with Stage 3-5 Chronic Kidney Disease and Left Ventricular Diastolic Dysfunction Cardiorenal Med 2014;4:

Paroxetine, Cognitive Therapy or Their Combination in the Treatment of Social Anxiety Disorder with and without Avoidant Personality Disorder: A Randomized.

A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice Kidney Blood Press Res 2017;42:468–482 -

Pre-Interventional Kynurenine Predicts Medium-Term Outcome after Contrast Media Exposure Due to Coronary Angiography Kidney Blood Press Res 2017;42:244–256.

Renalase, a Novel Enzyme Involved in Blood Pressure Regulation, Is Related to Kidney Function but Not to Blood Pressure in Hemodialysis Patients Kidney.

Cell Physiol Biochem 2013;32: DOI: /

Association of very Low-density Lipoprotein Cholesterol with All-cause and Cardiovascular Mortality in Peritoneal Dialysis Kidney Blood Press Res 2017;42:52–61.

Factors Associated with Blood Pressure Variability Based on Ambulatory Blood Pressure Monitoring in Subjects with Hypertension in China Kidney Blood Press.

T Lymphocyte Transmigration

Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent.

Cell Physiol Biochem 2015;37: DOI: /

Quantitative Analysis of Abdominal Aortic Calcification in CKD Patients Without Dialysis Therapy by Use of the Agatston Score Kidney Blood Press Res 2013;38:

Detection of Renal Hypoxia in Lupus Nephritis Using Blood Oxygen Level-Dependent MR Imaging: A Multiple Correspondence Analysis Kidney Blood Press Res.

Quantitative Renal Echogenicity as a Tool for Diagnosis of Advanced Chronic Kidney Disease in Patients with Glomerulopathies and no Liver Disease Kidney.

The Clinical Significance of Uric Acid and Complement Activation in the Progression of IgA Nephropathy Kidney Blood Press Res 2016;41: DOI: /

Fractional Excretion of Uric Acid as a Predictor for Saline Responsiveness in Long-Term Kidney Transplant Patients Kidney Blood Press Res 2012;35:627–633.

Effect of Salt Intake on Serum Glucagon-Like Peptide-1 Levels in Normotensive Salt-Sensitive Subjects Kidney Blood Press Res 2017;42:728–737 - DOI: /

Kidney Blood Press Res 2013;37: DOI: /

Representative flow cytometry dot plots from a healthy individual

Disease Progression Modeling to Evaluate the Effects of Enzyme Replacement Therapy on Kidney Function in Adult Patients with the Classic Phenotype of Fabry.

Significance of Urine Diagnostic Tests After Renal Transplantation

Plasma Cell Leukemia Presenting as a Chest Wall Mass: A Case Report

Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia Jacob J. Christensen,

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised,

Heart Rate, Life Expectancy and the Cardiovascular System: Therapeutic Considerations Cardiology 2015;132: DOI: / Fig. 1. Semilogarithmic.

Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor Preston E. Bratcher, Steven M. Rowe, Ginger.

The Effect of Antiretroviral Naïve HIV-1 Infection on the Ability of Natural Killer Cells to Produce IFN-γ upon Exposure to Plasmodium falciparum-Infected.

Cell Physiol Biochem 2016;38: DOI: /

Reduced endothelial progenitor cells in extracranial arterial stenosis but not intracranial arterial stenosis Zhixin Huang, MD, PhD, Xiaohao Zhang, MD,

CD56+/CD16− Natural Killer cells expressing the inflammatory protease granzyme A are enriched in synovial fluid from patients with osteoarthritis P.

Lymphocyte migration.

CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood by Mohamed F. Elshal,

Case Rep Ophthalmol 2013;4: DOI: /

Volume 84, Issue 1, Pages (July 2013)

Intra-Arterial Mechanical Thrombectomy: An Effective Treatment for Ischemic Stroke Caused by Endocarditis Case Rep Neurol 2016;8:229–233 - DOI: /

Volume 141, Issue 1, Pages e2 (July 2011)

Ca2+ Entry, Oxidative Stress, Ceramide and Suicidal Erythrocyte Death Following Diosgenin Treatment Cell Physiol Biochem 2016;39:

CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection by Rodolfo Silva, Susan Moir,

Volume 117, Issue 2, Pages (August 1999)

IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis Stéphanie.

Kidney Blood Press Res 2014;39: DOI: /

CD56+/CD16− Natural Killer cells expressing the inflammatory protease granzyme A are enriched in synovial fluid from patients with osteoarthritis P.

Figure 5 Treatment with fingolimod raises the activation threshold of monocytes in MS Peripheral blood mononuclear cells from 8 healthy donors, 7 patients.

Volume 132, Issue 1, Pages (January 2007)

Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion by John D. Belcher, Paul H. Marker,

Volume 153, Issue 5, Pages e2 (November 2017)

Increased Soluble CD226 in Sera of Patients with Cutaneous T-Cell Lymphoma Mediates Cytotoxic Activity against Tumor Cells via CD155 Naomi Takahashi,

Effect of First-Line Treatment on Myeloid-Derived Suppressor Cells’ Subpopulations in the Peripheral Blood of Patients with Non–Small Cell Lung Cancer

Volume 83, Issue 6, Pages (June 2013)

Increased chemokine content and leukocyte infiltrate in D6-negative tumors. Increased chemokine content and leukocyte infiltrate in D6-negative tumors.

Jerome A. Sigua, MD, Becky Buelow, MD, Dorothy S

Differential expression of functional chemokine receptors on human blood and lung group 2 innate lymphoid cells Cathryn A. Weston, PhD, Batika M.J. Rana,

Increased Neutrophil Adherence in Psoriasis: Role of the Human Endothelial Cell Receptor Thy-1 (CD90) Anne Wetzel, Tino Wetzig, Uwe F. Haustein, Michael.

Volume 58, Issue 3, Pages (September 2000)

Blockade of CD11a by Efalizumab in Psoriasis Patients Induces a Unique State of T-Cell Hyporesponsiveness Emma Guttman-Yassky, Yulia Vugmeyster, Michelle.

Volume 22, Issue 3, Pages (March 2005)

Hypertension promotes integrin expression and reactive oxygen species generation by circulating leukocytes Choong H. Kim, Nosratola D. Vaziri Kidney.

Xenon has no effect on cytokine balance and adhesion molecule expression within an isolated cardiopulmonary bypass system†‡ A. Bedi, W.T. McBride, M.A.

A.K.I. Kuroki, Masayuki Iyoda, Takanori Shibata, Tetsuzo Sugisaki

Pressure distension stimulates the expression of endothelial adhesion molecules in the human saphenous vein graft Massimo Chello, MD, Pasquale Mastroroberto,

Acquisition and alteration of adhesion molecules during cultured human mast cell differentiation Hiroshi Tachimoto, MD, PhD, Sherry A. Hudson, MSB, Bruce.

Volume 65, Issue 3, Pages (March 2004)

Diclofenac treatment reduces L-selectin on peripheral blood and infiltrated leukocytes but does not alter accumulation in the injured spinal cord. Diclofenac.

Molecular Therapy - Methods & Clinical Development

Joachim Boldt, Bernd Kumle, Michael Papsdorf, Gunter Hempelmann

Presentation transcript:

The Effects of Arterial Blood Pressure Reduction on Endocan and Soluble Endothelial Cell Adhesion Molecules (CAMs) and CAMs Ligands Expression in Hypertensive Patients on Ca-Channel Blocker Therapy Kidney Blood Press Res 2013;37:103-115 - DOI:10.1159/000350064 Fig. 1. The plasma soluble cell adhesion molecules (sCAMs): ICAM-1 (panel A), E-selectin (panel B) and VCAM-1 (panel C) concentrations before (white bars) and after (gray bars) the normalization of blood pressure with amlodipine therapy. Data are expressed as mean ± SD for N=24 patients; p- value of each relation is expressed at the panels. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

The Effects of Arterial Blood Pressure Reduction on Endocan and Soluble Endothelial Cell Adhesion Molecules (CAMs) and CAMs Ligands Expression in Hypertensive Patients on Ca-Channel Blocker Therapy Kidney Blood Press Res 2013;37:103-115 - DOI:10.1159/000350064 Fig. 2. The serum endocan concentration before (white bar) and after (gray bar) the amlodipine therapy is shown at Panel A. Panel B shows significant positive correlation of plasma sICAM-1 and endocan concentration. Data are expressed as mean ± SD for N=24 patients; 45 results are plotted on the graph, p value of each relation is expressed at the panels. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

The Effects of Arterial Blood Pressure Reduction on Endocan and Soluble Endothelial Cell Adhesion Molecules (CAMs) and CAMs Ligands Expression in Hypertensive Patients on Ca-Channel Blocker Therapy Kidney Blood Press Res 2013;37:103-115 - DOI:10.1159/000350064 Fig. 3. Level of ICAM-1, VCAM-1 and E selectin ligands was assessed by flow cytometry, and their expression presented as the geometric mean of fluorescence intensity determined by subtracting geometric mean fluorescence intensity of the isotype control from geometric mean fluorescence intensity of the specific mAb. The representative side scatter versus forward scatter plot defining leukocytes subpopulations (R1 - lymphocytes, R2 - granulocytes, R3 - monocytes) is shown on Panel A. Panel B shows representative histograms for determination of CD11a/LFA-1 (ICAM-1 and endocan ligand), CD15 (E-selectin ligand) and CD49d/VLA-4 (VCAM-1 ligand) expression on lymphocytes (R1 gate on panel A). Panel C shows different pattern of expression of CD11a, Cd15 and CD49d on the lymphocytes, monocytes and granulocytes before (white bar) and after (gray bar) the amplodipin treatment. All three ligands showed different pattern of expression on various cell types (Panel C; p≤0.001).(N = 10 patients, before and after the therapy). © 2013 S. Karger AG, Basel - CC BY-NC 3.0

The Effects of Arterial Blood Pressure Reduction on Endocan and Soluble Endothelial Cell Adhesion Molecules (CAMs) and CAMs Ligands Expression in Hypertensive Patients on Ca-Channel Blocker Therapy Kidney Blood Press Res 2013;37:103-115 - DOI:10.1159/000350064 Fig. 4. Correlation between soluble cell adhesion molecules concentration with systolic and diastolic blood pressures - sICAM-1 and systolic (A, left) and diastolic (A, right) blood pressure; and VCAM-1 and systolic (B, left) and diastolic (B, right) blood pressure. In addition, correlation between the degree of blood pressure reduction (ΔBP) and the degree of sVCAM-1 change (ΔsVCAM-1) is shown on panel C. There is a significant positive correlation of both sCAMs with BP, and a significant negative correlation between ΔsVCAM-1 and Δ diastolic BP. p value of each relation is expressed at the panels. 36 resuts are plotted at the pannels A and B, and 17 at the panel C. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

The Effects of Arterial Blood Pressure Reduction on Endocan and Soluble Endothelial Cell Adhesion Molecules (CAMs) and CAMs Ligands Expression in Hypertensive Patients on Ca-Channel Blocker Therapy Kidney Blood Press Res 2013;37:103-115 - DOI:10.1159/000350064 Fig. 5. Correlation between CD11a/LFA-1 expression on peripheral blood lymphocytes (A), granulocytes (B) and monocytes (C) with systolic (left panels) and diastolic blood pressures (right panels). There is a significant positive correlation of CD11a with BP; p value of each relation is expressed at the panels; 18 resuts are plotted at each graph. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

The Effects of Arterial Blood Pressure Reduction on Endocan and Soluble Endothelial Cell Adhesion Molecules (CAMs) and CAMs Ligands Expression in Hypertensive Patients on Ca-Channel Blocker Therapy Kidney Blood Press Res 2013;37:103-115 - DOI:10.1159/000350064 Fig. 6. Shematic presentation of the potential mechanism of blood pressure reduction on cell adhesion molecules' interaction with their ligands on circulatory leukocyte sub-population, and the potential counter-balancing role of endocan. In hypertension, there is high concentration of ICAM-1 and VCAM-1, with low E-selectin on endothelium, as markers of endothelial cell activation. This is accompanied with high adherence of leukocytes via LFA-1 and VLA-4 interaction with endothelium. Endocan, released by activated endothelium competes with ICAM-1 for LFA-1 thus disturbing the leukocyte adherence (hypothetical protective effect of endocan; left side of the Figure 6). With blood pressure reduction, there is decrease in ICAM-1, VCAM-1 expression and concomitant increase in the expression of their ligands LFA-1 and VLA-4 on possibly detached leukocytes, accompanied by the decrease in endocan secretion (right side of the Figure 6). Endocan, released by activated endothelium competes with ICAM-1 for LFA-1 thus disturbing the leukocyte adherence (hypothetical protective effect of endocan; left side of the Figure 6). With blood pressure reduction, there is decrease in ICAM-1, VCAM-1 expression and concomitant increase in the expression of their ligands LFA-1 and VLA-4 on possibly detached leukocytes, accompanied by the decrease in endocan secretion (right side of the Figure 6). © 2013 S. Karger AG, Basel - CC BY-NC 3.0