The bipotential gonad is differentiated into testes by the sex-determining region gene on the Y chromosome (Sry). This period of sex determination is followed.

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The bipotential gonad is differentiated into testes by the sex-determining region gene on the Y chromosome (Sry). This period of sex determination is followed by gonad differentiation of the different cell types of the testis. The Sertoli cells of the testis secrete müllerian-inhibiting substance (MIS or antimüllerian hormone [AMH]). The Leydig cells produce testosterone and insulin-like peptide 3 (INSL3). AMH (MIS) produces regression of the müllerian ducts. Testosterone stimulates the growth and differentiation of the wolffian ducts, growth of the penis and prostate. INSL3 participates in testicular descent; the final step in male sexual development. 5α-Dihydrotestosterone (DHT) produced from testosterone also participates in testis descent and development of the prostate. Source: Chapter 8. Male Reproductive System, Endocrine Physiology, 4e Citation: Molina PE. Endocrine Physiology, 4e; 2013 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/moli4/moli4_c008f005.png&sec=42541380&BookID=507&ChapterSecID=42540508&imagename= Accessed: October 16, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved