Volume 75, Issue 1, Pages (January 2010)

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Volume 75, Issue 1, Pages 229-234 (January 2010) Biocompatibility of New Drug-eluting Biodegradable Urethral Stent Materials Andres Kotsar, Riina Nieminen, Taina Isotalo, Joonas Mikkonen, Ilkka Uurto, Minna Kellomäki, Martti Talja, Eeva Moilanen, Teuvo L.J. Tammela Urology Volume 75, Issue 1, Pages 229-234 (January 2010) DOI: 10.1016/j.urology.2009.03.016 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 (A) Schematic diagram of Human Cytokine Antibody Array showing locations of controls and spots of proteins. Pos, positive control; Neg, negative control; Ena, epithelial neutrophil activating peptide; GCSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; GRO, growth-related oncogene; I-309, glycoprotein secreted by T lymphocytes; IL, interleukin; IFN, interferon; MCP, monocyte chemoattractant protein; MCSF, macrophage colony-stimulating factor; MDC, macrophage-derived chemokine; MIG, monokine induced by IFN-γ; MIP, macrophage inflammatory protein; RANTES, regulated on activation, normal T cells expressed and secreted; SCF, stem cell factor; SDF, stromal cell-derived factor; TARC, Thymus and activation regulated chemokine; TGF, transforming growth factor; TNF, tumor necrosis factor; EGF, epidermal growth factor; IGF, insulin-like growth factor; VEGF, vascular endothelial growth factor; PDGF, platelet-derived growth factor; BDNF, brain-derived neutrotrophic factor; BLC, B-lymphocyte chemoattractant; Ck, chemokine; FGF, fibroblast growth factor; Flt, Fms-like tyrosine kinase; GCP, granulocyte chemotactic protein; GDNF, glial cell-derived neutrotrophic factor; HGF, hepatocyte growth factor; IGFBP, IGF binding protein; IP, IFN-γ-inducible protein; LIF, leukemia inhibitory factor; LIGHT, lymphotoxins, exhibits inducible expression, and competes with herpes simplex virus (HSV) glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes; MIF, macrophage migration inhibitory factor; MIP, macrophage inflammatory protein; NAP, neutrophil activating protein; NT, neutrotrophic factor; PARC, pulmonary and activation-regulated chemokine; PIGF, placental growth factor; TIMP, tissue inhibitor of metalloproteinase. (B) Image of Human Cytokine Antibody Array membrane with culture media from THP-1 cells after 96 hours of incubation. (C) Effect of poly-96L/4D-lactic acid (PLA) stent material on inflammatory mediators in THP-1 cells. Protein secretion into culture medium after 96 hours of incubation detected by protein antibody array. Representative membrane of 4 shown, with similar results. Urology 2010 75, 229-234DOI: (10.1016/j.urology.2009.03.016) Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 2 Histologic picture of poly-96L/4D-lactic acid (PLA)-dexamethasone (high concentration) blended rod inducing calcification and minimal fibrosis at 3 months. Hematoxylin-eosin stain, original magnification ×40. Urology 2010 75, 229-234DOI: (10.1016/j.urology.2009.03.016) Copyright © 2010 Elsevier Inc. Terms and Conditions