Impact of the Triglycerides to High-Density Lipoprotein Cholesterol Ratio on the Incidence and Progression of CKD: A Longitudinal Study in a Large Japanese.

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Impact of the Triglycerides to High-Density Lipoprotein Cholesterol Ratio on the Incidence and Progression of CKD: A Longitudinal Study in a Large Japanese Population Kazuhiko Tsuruya, MD, PhD, Hisako Yoshida, PhD, Masaharu Nagata, MD, PhD, Takanari Kitazono, MD, PhD, Kunitoshi Iseki, MD, PhD, Chiho Iseki, PhD, Shouichi Fujimoto, MD, PhD, Tsuneo Konta, MD, PhD, Toshiki Moriyama, MD, PhD, Kunihiro Yamagata, MD, PhD, Ichiei Narita, MD, PhD, Kenjiro Kimura, MD, PhD, Masahide Kondo, MD, MSc, PhD, Koichi Asahi, MD, PhD, Issei Kurahashi, PhD, Yasuo Ohashi, PhD, Tsuyoshi Watanabe, MD, PhD American Journal of Kidney Diseases Volume 66, Issue 6, Pages 972-983 (December 2015) DOI: 10.1053/j.ajkd.2015.05.011 Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Flow chart of study participants. ∗Essential data: age; sex; systolic blood pressure; diastolic blood pressure; levels of hemoglobin A1c, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides; waist circumference; information on smoking, alcohol consumption, and exercise habits; histories of stroke and heart disease; and medication for hypertension, diabetes mellitus, and dyslipidemia. Abbreviations: CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate. American Journal of Kidney Diseases 2015 66, 972-983DOI: (10.1053/j.ajkd.2015.05.011) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Change in estimated glomerular filtration rate (eGFR) according to quartile (Q) of triglycerides to high-density lipoprotein cholesterol (TG:HDL-C) ratio (results of study 1). The 2-year changes in eGFR according to quartiles of TG:HDL-C ratio based on (A) baseline eGFR-adjusted and (B) multivariable-adjusted regression models are shown. Each bar represents the least square mean of the change in eGFR during the 2-year study period (eGFR at 2 years minus eGFR at baseline) and each vertical line represents the standard error of the mean. American Journal of Kidney Diseases 2015 66, 972-983DOI: (10.1053/j.ajkd.2015.05.011) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Change in estimated glomerular filtration rate (eGFR) according to quartile (Q) of triglycerides to high-density lipoprotein cholesterol (TG:HDL-C) ratio stratified by various variables (results of study 1). The 2-year changes in the eGFR based on a multivariable-adjusted regression model stratified by (A) sex, (B) diabetes mellitus, (C) hypertension, and (D) obesity are shown. Each bar represents the least square mean of the change in eGFR during the 2-year study period (eGFR at 2 years minus eGFR at baseline) and each vertical line represents the standard error of the mean. American Journal of Kidney Diseases 2015 66, 972-983DOI: (10.1053/j.ajkd.2015.05.011) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Odds ratio for incident chronic kidney disease (CKD) according to quartile (Q) of triglyceride to high-density lipoprotein cholesterol (TG:HDL-C) ratio stratified by various variables (results of study 2). Odds ratios for incident CKD according to the quartile of TG:HDL-C ratio stratified by sex, diabetes mellitus, hypertension, and obesity are shown. American Journal of Kidney Diseases 2015 66, 972-983DOI: (10.1053/j.ajkd.2015.05.011) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions