Immunoglobulin heavy-chain (IGHC) gene complex

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Presentation transcript:

Immunoglobulin heavy-chain (IGHC) gene complex Immunoglobulin heavy-chain (IGHC) gene complex. The heavy-chain genes encoding the constant regions are represented by blue boxes. Switch regions are represented by a filled circle upstream of the IGHC genes. Enhancers are represented by light blue circles. Each IGHV, IGHD and IGJH gene is labeled on the right of each symbol. Functional IGHV, IGHD, and IGHJ genes are represented by green boxes or blue and yellow lines, respectively. IGHV, IGJH, and IGHC pseudogenes are represented by red, orange boxes, or blue open boxes, respectively. IGHV and IGHC open-reading frames are represented by yellow and blue dashed boxes, respectively. Unrelated pseudogenes are represented by purple open boxes. Colors are according to IMGT color menu for genes. (Used with permission of Marie-Paule Lefranc. IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org.) Source: Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production, Williams Hematology, 9e Citation: Kaushansky K, Lichtman MA, Prchal JT, Levi MM, Press OW, Burns LJ, Caligiuri M. Williams Hematology, 9e; 2015 Available at: http://hemonc.mhmedical.com/DownloadImage.aspx?image=/data/books/1581/kau_ch75_f004.png&sec=108068104&BookID=1581&ChapterSecID=108068055&imagename= Accessed: October 14, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved