The flux of arginine after ischemia-reperfusion in the rat kidney

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Presentation transcript:

The flux of arginine after ischemia-reperfusion in the rat kidney Hubert A. Prins, Robert J. Nijveldt, Dorien V. Gasselt, Folkert Van Kemenade, Tom Teerlink, Anton A. Van Lambalgen, Jan A. Rauwerda, Paul A.M. Van Leeuwen Kidney International Volume 62, Issue 1, Pages 86-93 (July 2002) DOI: 10.1046/j.1523-1755.2002.00409.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Diagram of the experimental model. Abbreviations are: SAL, saline-treated; I-R, ischemia-reperfused kidney; C-L, contralateral kidney; ASE, arginase-treated; min, minutes. Note that all data presented in the Results section were obtained at the end of the experiment (t = 270 min). Kidney International 2002 62, 86-93DOI: (10.1046/j.1523-1755.2002.00409.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Kidney fluxes are presented in nmol 100 g BW-1· min-1 and data are means ± SEM for all groups. BW is body weight. Symbols are: (▪) SAL/I-R; () SAL/C-L; () ASE/I-R; (□) ASE-C-L. Abbreviations are: SAL, saline-treated; I-R, ischemia-reperfused kidney; C-L, contralateral kidney; ASE, arginase-treated. (A) Arginine; *P < 0.005 for both SAL/C-L versus SAL/I-R and for ASE/C-L versus ASE/I-R; **P < 0.01 for ASE/C-L versus ASE/I-R; and ***P < 0.05 for ASE/C-L versus SAL/C-L. (B) Citrulline; *P < 0.01 both for SAL/C-L versus SAL/I-R and ASE/C-L versus ASE/I-R. (C) Glutamine; *P < 0.01 both for SAL/C-L versus SAL/I-R and for ASE/C-L versus ASE/I-R. (D) Glutamate; *P < 0.01 for both SAL/C-L versus SAL/I-R and ASE/C-L versus ASE/I-R. (E). Ornithine; *P < 0.01 for both SAL/C-L versus SAL/I-R and ASE/C-L versus ASE/I-R. Kidney International 2002 62, 86-93DOI: (10.1046/j.1523-1755.2002.00409.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Examples of transverse kidney sections. Sections were cut and stained with routine H&E, magnification ×400. In panels A and B there is tubular damage. while no discernable changes are found in the contralateral kidney in arginase (C) and saline-treated (D) animals at the end of the experiment. Kidney International 2002 62, 86-93DOI: (10.1046/j.1523-1755.2002.00409.x) Copyright © 2002 International Society of Nephrology Terms and Conditions