From: External Validity of Clinical Trials in Acute Myocardial Infarction Arch Intern Med. 2007;167(1):68-73. doi:10.1001/archinte.167.1.68 Figure Legend: Patient inclusion flowchart. ACS indicates acute coronary syndrome; GRACE, Global Registry of Acute Coronary Events; LBBB, left bundle-branch block; NSTEMI, non–ST-segment elevation myocardial infarction; STE, ST-segment elevation; RCT, randomized clinical trial. Date of download: 10/11/2017

From: External Validity of Clinical Trials in Acute Myocardial Infarction Arch Intern Med. 2007;167(1):68-73. doi:10.1001/archinte.167.1.68 Figure Legend: Selected hospital outcomes and postdischarge to 6-month mortality. Unadjusted P<.001 across the 3 groups for all outcomes. RCT indicates randomized clinical trial. Reported P values adjusted for variables in the GRACE (Global Registry of Acute Coronary Events) risk model plus reperfusion and delay from symptom onset to arrival at the hospital. Date of download: 10/11/2017

From: External Validity of Clinical Trials in Acute Myocardial Infarction Arch Intern Med. 2007;167(1):68-73. doi:10.1001/archinte.167.1.68 Figure Legend: Crude and adjusted odds ratios (95% confidence intervals) for hospital death comparing eligible patients vs randomized clinical trial (RCT) participants. *Adjusted for GRACE (Global Registry of Acute Coronary Events) risk score, use and type of reperfusion (primary percutaneous coronary intervention only, fibrinolytic only, both, or neither), and delay from symptom onset to hospital admission (<2, 2-5.9, and ≥6 hours); P = .38 for reperfusion by trial type interaction in eligible patients vs RCT participants. †Adjusted for the GRACE risk score. Date of download: 10/11/2017