also a patient a patient a patient a patient Torus Medical has developed a new Invertible Pliant Sleeve, described below. The sleeve may be used in two different ways: Preparation to colonoscopy which involves cleaning (in one of two ways, depend on willing of patient). After preparation of the patient (not depended of method of cleaning), new sleeve with camera will be inserted to the cecum of the patient for diagnostic of the colon. A detailed description of the sleeve can be found below. A description of the cleaning process, performed both by a nurse and by the patient can be found below. A description of the diagnostic process can be found below. To continue press PageDown

To continue press PageDown (Anaconda) : Packed section of the Pliant Colonic Sleeve To continue press PageDown

Preparation to colonoscopy which involves cleaning with Invertible Pliant Sleeve The sleeve, 1.5-1.7 meters in length, 15 mm diameter, 40 micron thickness is folded so as to form a “packet”. This packet is folded internally in the sleeve (the internally folded section is referred to as “bukhta”). The transition of the tube, from the closed packet to it’s full length, is done by flowing water into the tube. The packet is folded in a proprietary manner – allowing each part that expands to remain static In it’s place, allowing the tube to progressively expand, which results in the “bukhta” being the only moving part, until it reaches the cecum. The water pressure is up to 0.4 atmospheres. Higher pressure will result in a rupture of the sleeve. The advantages of this method are: 1. The Torus method works according to and in parallel to the peristaltic movement of the bowel, as opposed to regular enema methods that work against the peristaltic movement. 2. The Torus method, due to this progressive expansion completely eliminated the possibility of bacteria from the anus to reach the cecum. 3. The Torus method is simple and quick – about 50 minutes total. 4. The procedure can be performed by a nurse or technician, it does not require a doctor. Air must not be inserted in the procedure. Water must go through tank, not directly from tap. To continue press PageDown

Besides All will be demonstrated in the following clip Advantages The advantages of this method are: 1. The Torus method works according to and in parallel to the peristaltic movement of the bowel, as opposed to regular enema methods that work against the peristaltic movement. 2. The Torus method, due to this progressive expansion completely eliminated the possibility of bacteria from the anus to reach the cecum. 3. The Torus method is simple and quick – about 50 minutes total (including colon cleaning and diagnostic). 4. The procedure can be performed by a nurse or technician, it does not require a doctor. 5. Anesthesia (local or general) is not required. 6. Insertion of the sleeve lasts 60-90 seconds. 7. All the materials and parts are disposable and are designed for a single use (the camera capsule is reusable) Air must not be inserted in the procedure. Water must go through tank, not directly from tap. All will be demonstrated in the following clip To continue press PageDown

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Cleansing Process – Performed by nurse : To continue press PageDown

Insert the Main tube about 4-5 cm into rectum Water Inlet: fill water, inflate balloon. Inflated balloon is used to keep the Main tube in the rectum. To continue press PageDown 2.1.2011 ver 6

To continue press PageDown Insert the Sleeve and fixate it inside the Close Cup Sleeve water filling port To continue press PageDown

To continue press PageDown Insert Sleeve into the Main tube. Inner diameter of Main tube allows to Sleeve to pass easily inside. Drainage tube port Sleeve water filling port Distance between proximal end of the sleeve and distal end of the Main tube is kept about 2 cm that allows easy drainage To continue press PageDown

To continue press PageDown 3. Water is inserted via tube to balloon 4. Sleeve (Anaconda) is connected to water filling port To continue press PageDown

Cleansing Process – Performed by patient : The patient inserts the sleeve and “bukhta” into the anal cavity and begins pumping water, which allows the “bukhta” to progress and unfold the sleeve, progressing towards the cecum. To continue press PageDown

At this stage the water is pumped into the cecum At this stage the water is pumped into the cecum. When the patient feels pressure in the stomach area, the sleeve is extracted and the patient passes the excrements. To continue press PageDown

Camera Capsule Insertion – Production and preparation Torus Medical has developed a diagnostic process which uses the operational principles previously described sleeve for the insertion of a camera capsule. This process is possible to perform on patients who have already gone through a cleansing process (the Torus process or otherwise). All the currently available camera capsules measure 11-12mm in diameter and 26-30mm in length. For this reason, the only difference in the invertible sleeve is a small increase in diameter. We use a cylinder measuring 15-16mm in internal diameter and 30mm in length, with threads used to attaching the camera. This cylinder is attached to the end of the sleeve. The sleeve is wrapped over the cylinder, and the edge of the sleeve is partially inverted, so that the threads remain accessible. In this form the sleeve is shipped to the medical facility. To continue press PageDown

Camera Capsule Insertion – process done by the nurse The only actions required of the nurse are as follows: The nurse has to attach the camera capsule by the threads and insert the capsule into the cylinder, and attach the device to a water tank, as described in the cleansing process. During the next phase, water is pumped into the sleeve exactly the same was as in the cleansing process. When the sleeve is fully unwrapped, the water pressure causes the camera capsule to protrude to the distance corresponding to the length of the threads. The sleeve is then slowly pulled out, together with the camera capsule, while the camera is filming its surroundings, transmitting an online video to the doctor. Usually %70-75 of the patients conclude the treatment at this stage, since no problems were discovered. The remaining %25-30 have polyps or other problems discovered. The polyps or other problematic areas are colored and the patients are directed to a doctor for further examination. The coloring allows the doctor to easily locate and identify the polyps. At the end of the process the camera is sent to disinfection, and it can be reused. To continue press PageDown

Advantages of the diagnostic process The advantages of this method are: The Torus method is quick and simple, the whole process takes about 10 minutes. The sleeve is disposable, but the camera capsule may be re-used, same as in a colonoscope, which makes the process extremely cost effective. The insertion process is identical to the cleaning process. To continue press PageDown

Business Plan $ per unit units in 1 Revenue Per Hour Monthly Revenue Annual Revenue Sale Price $ 400 2.0 $ 800 $ 136,000 $ 1,632,000   Cost Per Hour Monthly Cost Annual Cost Disposable set\kit $ 50 $ 100 $ 17,000 $ 204,000 Nurse $ 25 $ 50 $ 8,500 $ 102,000 Treatment Room $ 1,700 170.0 $ 10 $ 1,700 $ 20,400 ??? $ - $ - $ - $ - Total (Var) Cost $ 160 $ 27,200 $ 326,400 Total Profit $ 640 $ 108,800 $ 1,305,600 Comment - In the US the price for colonoscopy is $300, without cleanig Our price of $400 includes an additional fee of $100 for cleaning .

Profit estimation Taking into account that 2 patients are treated per hour, 340 per month and 4080 per year, and each patient pays $100 for cleaning and $300 for colonoscopy, the profit will be as follows: $640 per hour $108,800 per month $1,305,600 per year To continue press PageDown